Pathology Presents: Using pluripotent stem cells to develop models, dissect pathways, and discover new therapeutics
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Jessica Young, PhD
Department of Pathology
University of Washington
- Faculty Sponsor
Using pluripotent stem cells to develop models, dissect pathways, and discover new therapeutics for sporadic Alzheimer’s disease
Late-onset sporadic Alzheimer’s disease (SAD) is the most common cause of neurodegeneration in the elderly and a growing public health issue. Our lab is working to use patient stem cell-derived neurons to develop an accurate cellular model of SAD. With this model, we will investigate how genes that are associated with SAD risk in population studies impact cellular mechanisms leading to disease. I will give an overview of the projects being initiated in our laboratory, which will focus on the role of the endocytic network in AD pathogenesis.