4-Dimensional Genomic Nuclear Organization of Mammalian Embryogenesis Center
This new center, one of several across the country, explores changes in the organization of the nucleus over time in living cells and systems. The center will compile a high-resolution atlas of mouse embryonic development, which will be made openly available to the scientific community.
The Alzheimer's Disease Research Center investigates the basic biological process underlying Alzheimer's disease and related memory disorders. With the commitment of their dedicated research team and volunteer participants, the Center aims to improve the functioning of people suffering from Alzheimer's disease and improve the quality of life of both patients and caregivers.
The Center for Cardiovascular Biology is dedicated to discovering the molecular basis of cardiovascular disease, harnessing this information to develop new therapies, and training the next generation of cardiovascular physicians and scientists.
The Center for Precision Diagnostics (CPDx) brings together programs that use multiple tools to provide the highest level of detail in genetic alterations that lead to inherited disorders and some acquired conditions.
The University of Washington launched the Healthy Aging and Longevity Research Institute, otherwise known as HALo, to support new research initiatives and encourage multi-disciplinary collaboration by aging research throughout the University. HALo aims to promote not just a long life, but lifelong well-being.
Heart Regeneration Program
The Heart Regeneration Program (HRP) has been established as a translational vehicle for developing and clinically testing a cell therapy for heart disease, based on the foundational work of Drs. Charles Murry and Michael Laflamme. These investigators have demonstrated that human embryonic stem-cell derived cardiomyocytes can be generated with high efficiency in theoretically unlimited quantities, and through a series of preclinical studies, that these cells improve heart function when transplanted into animal models of acute myocardial infarction. The mandate for the Heart Regeneration Program is to complete a Phase 1/2 clinical trial of human cardiomyocytes for treatment of acute myocardial infarction in the next 4 years. To execute the optimization of a clinical-grade therapeutic, and the IND-enabling preclinical safety and efficacy studies required for clinical testing, the program is staffed with a team of 9 scientists with over 95 collective years of R&D experience in the biotechnology and pharmaceutical sector.
The HPV Research Group is comprised of a variety of researchers from several institutions in Western Washington and Senegal, Africa that include the University of Washington, the Fred Hutchinson Cancer Research Center, and the University of Dakar. The group has conducted a variety of studies focused on HPV and HPV related cancers.
The University of Washington Institute for Stem Cell and Regenerative Medicine (ISCRM) is committed to the ethical pursuit of basic research to unleash the enormous potential of stem cells and thereby develop therapies and cures.
The Nathan Shock Center of Excellence in Basic Biology of Aging at the University of Washington provides leadership in the pursuit of basic research into the biology of aging and resources to support the large community of University of Washington investigators studying aspects of the basic biology of aging.
NWBioSpecimen (NWBioS) is a collaborative Fred Hutchinson/University of Washington/Seattle Children’s resource that connects donated biospecimens from consenting individuals with innovative research projects aimed at advancing biomarker discovery and improving prevention, diagnosis and treatment of human disease.
PANUC is collaboration among the University of Washington among the University of Washington, the VA Puget Sound Health Care System, Oregon Health & Science University, and the Portland VA Medical Center. PANUC is a multidisciplinary program bringing together academic, clinical, and research experts in the fields of movement disorders, memory disorders, and brain aging to study cognitive impairment in Parkinson’s disease.
The HMC Digital Pathology Facility provides diagnostic quality brightfield whole-slide histologic imaging services using Aperio ScanScope AT2 whole slide imaging systems and Aperio eSlide Manager server software. The resulting whole slide scans are web accessible and enable you to share whole slide images with collaborators, annotate regions of interest, and extract high resolution images suitable to prepare publication-quality figures at high and low magnifications. Once slides are scanned, they are viewable at any magnification up to the scan resolution (equivalent to viewing at 20X (0.50µm/pixel) or 40X (0.25µm/pixel) microscope objectives with 10X eyepieces). The resulting whole slide images are also available for quantitative analysis services by the NWBioSpecimen Digital Image Analysis Facility.
The Pathology Digital Image Analysis Facility, part of the NWBioSpecimen research services core facility, provides quantitative image analysis of selected features from digital whole slide images. Using Aperio Brightfield Image Analysis Toolbox software, we can annotate regions of interest and quantify histologic features and immunohistochemical staining within tissue objects, cells, or other areas. These quantification methods yield continuous variable data suitable for statistical analysis. These methods are easily adjustable to studies utilizing tissue microarrays (TMAs) for performing high-throughput analyses. Histologic slides may be scanned using the HMC Digital Pathology Facility and the resulting whole slide images are available for quantification by our facility.
The Pathology Research Services Laboratory at UW Medicine Department of Pathology provides expertise in a broad spectrum of morphologic studies required for interpretation of disease processes. Our laboratory provides routine histology and immunohistochemistry services at reasonable prices.
The International Registry of Werner Syndrome provides a central repository for data and materials in order to advance the progress of research and education relevant to this rare autosomal disorder that mimics premature aging.