Clinical and Research Background
I am interested in how abnormal cell cycle regulation impacts cell proliferation differentiation and stem cell maintenance focusing on myeloid disorders including myelodysplastic syndrome, myeloproliferative neoplasm and acute myeloid leukemia. Our current focus is on erythroid maturation using a function shRNA study to challenge cell cycle exit during erythropoiesis. We are also studying erythroleukemia arising from a Sleeping Beauty transposon mediated insertional mutagenesis in mice expressing a stabilized form of cyclin E.
My clinical service specializes in bone marrow transplant Pathology including accessing hematologic malignancy, graft-vs-host disease and infection in stem cell transplant patients.
Board Certifications
Hematopathology, Anatomic and Clinical Pathology
Academic and Medical Appointments
Professor, Translational Science and Therapeutics Division, Fred Hutch Cancer, Seattle, WA, 2024-present
Professor, Public Health Science Division, Fred Hutch Cancer Center, Seattle, WA, 2024-present
Professor, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 2024-present
Associate Member, Divisions of Clinical Research and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 2014-present
Associate Professor, Department of Pathology, University of Washington Medical Center, Seattle, WA, 2014-2024
Adjunct Associate Professor, Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, 2014-2024
Assistant Professor, Department of Pathology, University of Washington Medical Center, Seattle, WA, 2007-2014
Adjunct Assistant Professor, Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, 2008-2014
Education and Training
Hematopathology Fellowship, University of Washington Medical Center, Seattle, WA.
Senior Postdoctoral Fellowship with Jim Roberts, Fred Hutchinson Cancer Research Center, Seattle, WA.
Pathology Residency Training (Combined AP/CP), University of Washington Medical Center, Seattle, WA.
Medical College of Wisconsin, Milwaukee, WI, M.D.
Medical College of Wisconsin, Milwaukee, WI, Biochemistry, Ph.D.
Wesleyan University, Middletown, CT, Biology, B.A.
Publications
Latest publications from PubMed