Clinical and Research Background
Dr. Tait’s research focuses primarily on two areas: the annexin family of calcium-dependent phospholipid binding proteins, and clinical molecular-genetic testing. In the first area, the long-range goal is to understand the mechanism of annexin-membrane binding, and to develop better means to diagnose and treat disorders related to thrombosis and apoptosis. The interaction of annexin V with phospholipids, platelets, leukocytes, and erythrocytes has been characterized quantitatively. These results show that annexin V is an excellent probe for detection and functional inhibition of cellular procoagulant phospholipid (primarily phosphatidylserine). The structural requirements for membrane binding have been defined, and annexin V has been developed as a means to image apoptotic cells in vivo in clinical areas such as organ transplant rejection and cancer chemotherapy. In the second area, novel molecular-genetic clinical assays have been developed for the diagnosis and management of genetic and neoplastic diseases, and their analytical and clinical performance has been evaluated in the clinical laboratory setting.
Latest publications from PubMed