Hantavirus Antibodies, IgG and IgM (Sendout)

General Information

Lab Name

Lab Code

228

External Test Id

FHVGM

Description

Clinical Significance: Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus (SNV), which causes hantavirus pulmonary syndrome, a severe and sometimes fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States. Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All Hanta IgM positive samples from US residents will be sent to a Public Health Laboratory for SNV-specific IgM. Samples that are Hanta IgG positive but IgM negative are not subjected to SNV-specific IgM testing, since the lack of IgM rules out acute SNV infection. A positive Hanta IgM result but a negative SNV-specific IgM antibody result may indicate either reactivity to a hantavirus other than SNV or false positive reactivity. A small number of SNV IgM positive (but Hanta IgG negative) samples represent false positive reactivity associated with acute cytomegalovirus or Epstein Barr virus infection.

Ordering Requirements: This test requires approval from the Laboratory Medicine Resident (LMR) on-call. Contact the LMR via the paging officer at 206-598-6190.

Synonyms

FHVGM, Hantavirus Antibody

Interpretation

Method

Enzyme Linked Immunosorbent Assay (ELISA)

Ref. Range Notes

Reference Range: Negative

Guidelines

Ordering & Collection

Specimen Type

Blood

Collection

3 mL RED TOP tube (preferred) or GOLD SST

Approval Required

Laboratory Medicine Resident approval required.

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 14 days; Frozen: 30 days; Ambient: 7 days.

Quantity

requested: 1.0 mL serum
minimum: 0.5 mL serum

Processing

Centrifuge and transfer serum to a separate vial. Refrigerate.

Login: SEND1-;REFRIG

  • RSNDT1: MAYQID
  • RSTYP1: SRM
  • RTSRQ1: ;Hantavirus Antibodies, IgG & IgM (Mayo Test FHVGM)

Sendouts:

  • Order Mayo Test: FHVGM.

Stability: Refrigerated (preferred): 14 days; Frozen: 30 days; Ambient: 7 days.

Performance

LIS Dept Code

Performing Location(s)

Sendout Mayo forwards to Quest Diagnostics Infectious Diseases, Inc.
800-533-1710

33608 Ortega Highway
San Juan Capistrano, CA 92675

Frequency

Performed: Monday, Wednesday, Saturday. Report Available: 1-7 days.

Available STAT?

No

Billing & Coding

CPT codes

Billing Comments

CPTs: 86790x2

LOINC