Anti Neuronal Cell Antibody
General Information
Lab Name
Anti Neuronal Cell Ab
Lab Code
ANEUR
Epic Name
Anti Neuronal Cell Antibody
Description
Elevated serum or CSF anti-neuronal cell antibody levels may help in the diagnosis of neuropsychiatric systemic lupus erythematosus (SLE). This test should not be mistaken for the assay for anti-neuronal nuclear antibodies (ANNA), which include anti-Hu, Yo, and Ri antibodies. These other tests may be ordered to evaluate some forms of paraneoplastic peripheral neuropathies associated with various malignancies, and are not currently performed at the University of Washington (they are send-out tests).
References
- Ho RC, Thiaghu C, Ong H, Lu Y, Ho CS, Tam WW, Zhang MW. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev. 2016 Feb;15(2):124-38. doi: 10.1016/j.autrev.2015.10.003. Epub 2015 Oct 23. PMID: 26497108.
- West SG, Woodruff E, Wener MH, Kotzin BL. Neuropsychiatric Lupus Erythematosus: A 10-year prospective study on the value of diagnostic tests. Am J Med (1995) 99:153.
Components
| Code | Name |
|---|---|
| ANEU | Anti Neuronal Cell Ab |
| IINTP1 | Interpretation |
| ANMTH | Anti Neuronal Cell Ab Method |
Interpretation
Method
ELISA using stable, isolated neuronal membrane extracts.
Reference Range
See individual components
Ref. Range Notes
Established by testing healthy blood donor samples during method validation in 1987. Confirmed in 2005, 2010, 2012, 2015, and 2018.
Guidelines
Ordering & Collection
Specimen Type
Collection
3 mL blood in RED TOP or SST tube
Quantity
requested: 1 mL serum
minimum: 0.5 mL serum
Processing
Freeze serum at -20°C
Stability: Freezer: Long Term; Refrig: 14 d
Performance
LIS Dept Code
Immunology (IMM)
Performing Location(s)
| UW-MT |
Immunology
206-520-4600 Clinical Lab, Room NW220, |
|---|
Frequency
Monday, Wednesday
Available STAT?
No