Anti Neuronal Cell Antibody
General Information
Lab Name
Anti Neuronal Cell Ab
Lab Code
ANEUR
Epic Name
(not orderable in Epic)
Description
Elevated serum or CSF anti-neuronal cell antibody levels may help in the diagnosis of neuropsychiatric systemic lupus erythematosus (SLE). This test should not be mistaken for the assay for anti-neuronal nuclear antibodies (ANNA), which include anti-Hu, Yo, and Ri antibodies. These other tests may be ordered to evaluate some forms of paraneoplastic peripheral neuropathies associated with various malignancies, and are not currently performed at the University of Washington (they are send-out tests).
***Order Alert: Effective 11/20/2025, serum and cerebrospinal anti-neuronal cell antibody testing is temporarily unavailable due to an assay reagent issue. The duration of the downtime is unknown, but clients will be informed once testing resumes. Please contact Client Support Services at 206-520-4600 for any questions.***
References
- Ho RC, et al. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev 2016, 15:124-38. 26497108
- West SG, Emlen W, Wener MH, and Kotzin BL. Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests. Am J Med 1995, 99:153-63. 7625420
Components
| Code | Name |
|---|---|
| ANEU | Anti Neuronal Cell Ab |
| IINTP1 | Interpretation |
| ANMTH | Anti Neuronal Cell Ab Method |
Interpretation
Method
ELISA using stable, isolated neuronal membrane extracts.
Reference Range
See individual componentsRef. Range Notes
Established by testing healthy blood donor samples during method validation in 1987. Confirmed in 2005, 2010, 2012, 2015, and 2018.
Guidelines
Ordering & Collection
Specimen Type
Collection
Currently, new samples are not being accepted.
Processing
Performance
LIS Dept Code
Immunology (IMM)