D-Dimer Quantitative
General Information
Lab Name
D_Dimer Quant
Lab Code
DDI
Epic Name
D-Dimer, Quant
Description
The D-Dimer test is a quantitative immunoturbidimetric test - elevated levels may indicate the presence of pulmonary embolism, deep vein thrombosis, arterial thrombosis or DIC.
Additionally, the D-Dimer test can be used in conjunction with a clinical pretest probability assessment model to exclude approximately 95% of pulmonary embolism and deep vein thrombosis when the D-Dimer level is less than 0.5mcg/mL FEU with a low or moderate pretest PE probability.
Synonyms
Fibrin Degredation Products, Fibrin Split Products, XDP
Interpretation
Method
Optical
Reference Range
Units: mcg/mL FEU
| Female | Male | ||
|---|---|---|---|
| Age | Range | Age | Range |
| 0- | 0.00-0.59 | 0- | 0.00-0.59 |
Effective date: 04/26/2006
Ref. Range Notes
Quantitative D-Dimer levels less than 0.5 mcg/mL FEU can be used to exclude a diagnosis of pulmonary embolism or proximal DVT in the setting of low and moderate pretest probability. A negative result does not exclude the possibility of thrombosis, especially if pretest probability is high. This assay is reported in mcg/mL of fibrinogen equivalent units (FEU): 1 mcg/mL of D-dimer is equal to 2 mcg/mL of fibrin converted to D-dimer (FEU).
Interferences and Limitations
Fibrinogen degradation product concentrations greater than 15 ug/ml may lead to an over-estimation of the D-dimer level.
The presence of rheumatoid factor greater than 50 IU/ml may lead to an over-estimation of the D-dimer level.
The presence of anti-bovine albumin and/or anti-mouse antibodies in certain subjects may lead to an over-estimation of D-dimer level. Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibodies (HAMA). Such specimens may lead to an over-estimation of the D-dimer level. Please contact the Laboratory Medicine Resident on call at 206-598-6190 if you have questions about the D-dimer level in any patient that has received preparations of mouse monoclonal antibodies.
This test is insensitive to hemoglobin up to 2g/L, conjugated billrubin up to 290 mg/L, unconjugated billrubin up to 200 mg/L, and unfractionated heparin and low molecular weight heparin up to 2 IU/mL.
Ordering & Collection
Specimen Type
Collection
3 or 5 mL BLUE TOP (CITRATE) tube
Handling Instructions
UW-MT/HMC/UW-NW: Laboratory MUST process the specimen within 8 hours of blood collection.
FHCC: Specimens must be processed within 8 hours of collection.
Outside Laboratory: Centrifuge sample for 10 minutes, remove plasma & re-spin plasma for another 10 minutes to remove all platelets. Decant & freeze plasma (minimum 1.0 mL) @ -20°C to -80°C. Transport specimen frozen on dry ice.
Quantity
requested: Entire sample
minimum: 1.0 mL Citrated plasma
Processing
Take specimen to COAG lab
Stability: Whole blood samples must be processed within 8 hours of collection. Plasma samples frozen at -70°C or below are good for 1 year.
Performance
LIS Dept Code
Coagulation (COAG)
Performing Location(s)
| HMC |
Coagulation
206-520-4600 325 9th Ave, Rm # GWH-47, Seattle, WA 98104-2420 |
|
|---|---|---|
| UW-NW |
Main Lab
206-668-1344 UW Medical Center – Northwest |
|
| FHCC |
Fred Hutch Alliance Lab
206-606-1088 825 Eastlake Ave, Seattle, WA 98109 |
|
| UW-MT |
Coagulation
206-520-4600 Clinical Lab, Room NW220, |
Frequency
Daily
Available STAT?
Yes
Billing & Coding
CPT codes
85379
LOINC
Interfaced Order Code
UOW241
Interfaced Result Code
UOW241