Lupus Anticoagulant, DRVVT
General Information
Lab Name
Lupus Anticoagulant, DRVVT
Lab Code
LUPAC
Epic Name
Lupus Anticoagulant
Description
This Lupus Anticoagulant test uses Russell's viper venom to directly activate factors V and X, bypassing the tissue factor pathway and the contact and antihemophilic factor of the intrinsic pathway. The ratio of clotting times with excess phospholipid to that without excess phospholipid is used to determine the presence of lupus inhibitor in the plasma. This test will be added by the laboratory reflexively if Hexagonal Phospholipid assay is negative with prolonged PTT above 40 seconds.
For patients on Xa inhibitors (Apixaban, Rivaroxaban, Edoxaban), order Hexagonal Phospholipid assay (HEXPI) instead.
Interpretation
Method
Clot-based
Reference Range
Units: ratio
| Female | Male | ||
|---|---|---|---|
| Age | Range | Age | Range |
| 0- | 0.00-1.30 | 0- | 0.00-1.30 |
Effective date: 11/03/2014
Interferences and Limitations
Patients on direct oral anticoagulants (Bivalirudin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban) have prolonged clotting time with the DRVVT assay and may give false positive results depending on the drug concentration in the plasma.
Ordering & Collection
Specimen Type
Collection
Processing
Performance
LIS Dept Code
Coagulation (COAG)
Performing Location(s)
| HMC |
Coagulation, Special
206-520-4600 325 9th Ave, Rm # GWH-47, Seattle, WA 98104-2420 |
|---|
Frequency
Available STAT?
Billing & Coding
CPT codes
85613x2
LOINC
Interfaced Order Code
UOW2923
Interfaced Result Code
UOW2923