Laboratory Test Guide

Lupus Anticoagulant, DRVVT

General Information

Lab Name

Lupus Anticoagulant, DRVVT

Lab Code

LUPAC

Epic Name

Lupus Anticoagulant

Description

This Lupus Anticoagulant test uses Russell's viper venom to directly activate factors V and X, bypassing the tissue factor pathway and the contact and antihemophilic factor of the intrinsic pathway. The ratio of clotting times with excess phospholipid to that without excess phospholipid is used to determine the presence of lupus inhibitor in the plasma. This test will be added by the laboratory reflexively if Hexagonal Phospholipid assay is negative with prolonged PTT above 40 seconds.

For patients on Xa inhibitors (Apixaban, Rivaroxaban, Edoxaban), order Hexagonal Phospholipid assay (HEXPI) instead.

Interpretation

Method

Clot-based

Reference Range

Units: ratio

Female Male
AgeRangeAgeRange
0-0.00-1.30 0-0.00-1.30

Effective date: 11/03/2014

Interferences and Limitations

Patients on direct oral anticoagulants (Bivalirudin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban) have prolonged clotting time with the DRVVT assay and may give false positive results depending on the drug concentration in the plasma.

Ordering & Collection

Specimen Type

Collection

Processing

Performance

LIS Dept Code

Coagulation (COAG)

Performing Location(s)

HMC Coagulation, Special
206-520-4600

325 9th Ave, Rm # GWH-47, Seattle, WA 98104-2420

Frequency

Available STAT?

Billing & Coding

CPT codes

85613x2

LOINC

18720-3

Interfaced Order Code

UOW2923

Interfaced Result Code

UOW2923