Aquaporin-4 IgG Antibody, Serum (Sendout)
General Information
Lab Name
Aquaporin-4 IgG Antibody, Serum (Sendout)
Lab Code
RAQP4A
Epic Name
Aquaporin-4 IgG Antibody, Serum (Sendout)
External Test Id
NMOFS
Description
Useful For:
- Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
- Diagnosis of autoimmune AQP4 channelopathy
- Diagnosis of neuromyelitis optica (NMO)
- Distinguishing NMOSD from multiple sclerosis early in the course of disease
Testing Algorithm: If the FACS assay is positive at screening dilution, FACS Titer Assay is performed at an additional charge.
Synonyms
AQP, AQP4, Aquaporin, Devic's Antibody, NMO (Neuromyelitis Optica), NMO-IgG, NMOFS, Optic Neuritis Antibody, Optic-Spincal MS Ab, Soft-NMOS, Transverse Myelitis Antibody, Vision Loss Antibody
Components
| Code | Name |
|---|---|
| RNMAQS | Aquaporin-4 FACS Screen |
| RNMAQT | Aquaporin-4 FACS Titer |
Interpretation
Method
Flow Cytometry / Fluorescence-Activated Cell Sorting Assay (FACS)
Reference Range
See individual components
Ref. Range Notes
Interpretation: A positive value is consistent with a neuromyelitis optica spectrum disorder (NMOSD) and justifies initiation of appropriate immunosuppressive therapy at the earliest possible time. This allows early initiation and maintenance of optimal therapy. Recommend follow-up in 3 to 6 months if NMOSD is suspected.
This autoantibody is not found in healthy subjects.
Interferences and Limitations
Cautions: AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Ordering & Collection
Specimen Type
Collection
10 mL blood in RED TOP tube (preferred)
Also acceptable: GOLD TOP SST
Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate vial. Refrigerate serum.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Quantity
requested: 3 mL serum
minimum: 2 mL serum
Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: NMOFS.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Performance
LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories
800-533-1710 200 First Street Southwest |
|---|
Frequency
Performed: Monday, Tuesday, Thursday. Report Available: 5-8 days.
Available STAT?
No