Coccidioides Antibodies, CSF (Sendout)
General Information
Lab Name
Coccidioides Antibodies, CSF (Sendout)
Lab Code
RCCOCC
Epic Name
Coccidioides Antibodies, CSF (Sendout)
External Test Id
CCOC
Description
Useful For: Diagnosing coccidioidomycosis using spinal fluid specimens.
References
- Mayo Clinical & Interpretive Information: Coccidioides Antibody, Complement Fixation and Immunodiffusion, Spinal Fluid
- Washington State Department of Health Notifiable Conditions: Coccidioidomycosis (Valley Fever)
Synonyms
CCOC, Coccidioides Spinal Fluid, San Joaquin Valley Fever CSF, Valley Fever CSF
Components
| Code | Name |
|---|---|
| RCCOCF | Coccidioides Antibody by Complement Fixation,CSF |
| RCCIDG | Coccidioides IgG Antibody by Immunodiffusion, CSF |
| RCCIDM | Coccidioides IgM Antibody by Immunodiffusion, CSF |
Interpretation
Method
Complement Fixation (CF), Immunodiffusion (ID)
Reference Range
See individual components
Ref. Range Notes
Interpretation:
- Complement Fixation: IgG antibody is detected by complement fixation (CF) testing. Any CF titer in cerebrospinal fluid (CSF) should be considered significant. A positive complement fixation test in un-concentrated CSF is diagnostic of meningitis.
- Immunodiffusion: IgM and IgG precipitins are rarely found in CSF. However, when present, they are diagnostic of meningitis (100% specific). Since the immunodiffusion test is 100% specific, it is helpful in interpreting CF results.
Interferences and Limitations
Cautions: While complement fixation (CF) titers may be present in serum months after the infection has resolved, any CF titer in spinal fluid should be considered significant.
Guidelines
Ordering & Collection
Specimen Type
Collection
Collect 2 mL CSF in a sterile container.
Handling Instructions
Outside Laboratories: Submit 2 mL refrigerated CSF in a sterile vial.
Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.
Quantity
requested: 2 mL CSF
minimum: 1.2 mL CSF
Processing
Refrigerate CSF in a sterile vial.
Sendouts:
- Order Mayo Test: CCOC.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 14 days; Frozen: 14 days; Ambient: Unacceptable.
Performance
LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories (Superior Drive)
800-533-1710 3050 Superior Drive NW |
|---|
Frequency
Performed: Monday- Friday. Report Available: 3-6 days.
Available STAT?
No