MOG Antibodies (Sendout)
General Information
Lab Name
MOG Antibodies
Lab Code
RMOG
Epic Name
MOG Antibodies (Sendout)
External Test Id
MOGFS
Description
Useful For:
- Diagnosis of inflammatory demyelinating diseases (IDD) with similar phenotype to neuromyelitis optica (NMO) spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis
- Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy
- Diagnosis of NMO
- Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease
- Diagnosis of ADEM
- Prediction of a relapsing disease course
Testing Algorithm: When the results of this assay require further evaluation, the reflex titer test will be performed at an additional charge.
Patient Preparation: For optimal antibody detection, specimen collection should occur prior to initiation of immunosuppressant medication.
References
- Mayo Clinical & Interpretive Information: Myelin Oligodendrocyte Glycoprotein (MOG-IgG1) Fluorescence-Activated Cell Sorting (FACS) Assay, Serum
Synonyms
ADEM antibody, MOG IgG1, MOGFS, Myelin Oligodendrocyte Glycoprotein, NMO antibody, Optic Neuritis Antibody, Transverse Myelitis Antibody, Vision Loss Antibody
Components
| Code | Name |
|---|---|
| RMOGFS | MOGAb, FACS |
Interpretation
Method
Flow Cytometry
Reference Range
See individual componentsRef. Range Notes
| Reference Value: | Negative |
Interpretation:
A positive value for myelin oligodendrocyte glycoprotein (MOG)-IgG is consistent with a neuromyelitis optica-like phenotype and, in the setting of acute disseminated encephalomyelitis, optic neuritis and transverse myelitis, indicates an autoimmune oligodendrogliopathy with potential for relapsing course. Identification of MOG-IgG allows distinction from multiple sclerosis (MS) and may justify initiation of appropriate immunosuppressive therapy (not MS disease-modifying agents) at the earliest possible time. This allows early initiation and maintenance of optimal therapy. Recommend follow-up in 6 to 12 months, as persistence of MOG-IgG seropositivity predicts a relapsing course.
This autoantibody is not found in healthy subjects.
Interferences and Limitations
Cautions: Myelin oligodendrocyte glycoprotein (MOG)-IgG, specifically MOG-IgG1, may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Ordering & Collection
Specimen Type
Collection
6 mL blood in a RED TOP tube or GOLD SST
Handling Instructions
Outside Laboratories: Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
Quantity
requested: 2 mL serum
minimum: 1 mL Serum
Processing
Centrifuge sample and aliquot serum into a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: MOGFS
- Interfaced: Yes [Interface: 601; Worksheet: MARF]
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
Performance
LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories
800-533-1710 200 First Street Southwest |
|---|
Frequency
Performed: Monday, Tuesday, Thursday. Reported: 5-8 days from sample receipt at Mayo Clinic Labs.
Available STAT?
No