Paraneoplastic Autoantibody Evaluation, Serum (Sendout)
General Information
Lab Name
Paraneoplastic AutoAb Evaluation (Sendout)
Lab Code
RPNPEV
Epic Name
Paraneoplastic Autoantibody Evaluation (Sendout)
External Test Id
PAVAL
Description
Useful For:
- Serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer
- Directing a focused search for cancer
- Investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis
- Differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy
- Monitoring the immune response of seropositive patients in the course of cancer therapy
- Detecting early evidence of cancer recurrence in previously seropositive patients
- For a complete list of tests and potential reflex tests included in this panel, refer to the Mayo Paraneoplastic Evaluation Algorithm - Serum
Ordering Notes:
- Non-orderable battery included in the Paraneoplastic Autoantibody Evaluation, Serum (Sendout) [RPNPV] package.
- Individual antibody tests within the Paraneoplastic Autoantibody Evaluation are available for patients who have previously tested positive for those antibodies within the past five years at a Mayo laboratory. Refer to Mayo test: Neuroimmunology Antibody Follow-up, Serum.
Synonyms
PAVAL
Components
| Code | Name |
|---|---|
| RANN1 | Anti Neuronal Nuclear Antibody 1 |
| RANN2 | Anti Neuronal Nuclear Antibody 2 |
| RANN3 | Anti Neuronal Nuclear Antibody 3 |
| RAGNA1 | Anti Glial Nuclear Antibody 1 |
| RPCA1 | Purkinje Cell Cytoplasmic Antibody 1 |
| RPCA2 | Purkinje Cell Cytoplasmic Antibody 2 |
| RPCATR | Purkinje Cell Cytoplasmic Antibody Tr |
| RAMPHS | Amphiphysin Antibody |
| RCRMP | CRMP 5 IgG |
| RPNINT | Paraneoplastic Autoantibody Interpretation |
| RPNIFA | IFA Notes |
Interpretation
Method
Panel and reflex tests include the following methods: Immunofluorescence assay (IFA), Cell-binding assay (CBA), Western blot (WB), Radioimmunoassay (RIA), Immunoblot (IB)
Reference Range
See individual components
Ordering & Collection
Specimen Type
Collection
12 mL blood in RED TOP tubes or GOLD SST
Quantity
requested: 4 mL serum
minimum: 2 mL serum
Processing
Centrifuge samples and aliquot 4 mL serum (2 mL minimum) into a separate plastic vial. Refrigerate serum.
If individual antibodies are requested (with a previous positive result within the last 5 years at Mayo), refer to separate test guide #982 (Neuroimmunology Follow-up, PNEFS).
Sendouts:
- Order Mayo Test: PAVAL
- Interfaced: Yes [Interface: 601; Worksheet: MARF]
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, icterus.
Performance
LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories
800-533-1710 200 First Street Southwest |
|---|
Frequency
Performed: Monday - Sunday. Reflex tests: Varies. Report Available: 10-17 days from sample receipt at the performing laboratory.
Available STAT?
No