Q Fever Antibody Screen, Reflex to Titer (Sendout)
General Information
Lab Name
Q Fever Antibody Screen, Reflex to Titer (Sendout)
Lab Code
RQFVRS
Epic Name
Q Fever Antibody Screen, Reflex to Titer (Sendout)
External Test Id
QFEVR
Description
Useful For: Screening for exposure to Coxiella burnetii, the causative agent of Q fever. This test should not be used as a screening procedure for the general population.
Testing Algorithm: If the Q fever serology result is reactive, then Q Fever IgG and IgM Antibodies (Sendout) [RQFP] by indirect immunofluorescence will be performed at an additional charge.
Synonyms
Coxiella burnetii, Febrile Agglutinins, OS-K (Proteus OX-K - Weil-Felix), OX-19 (Proteus OX-19 - Weil-Felix), OX-2 (Proteus OX-2 - Weil-Felix), Proteus (Weil-Felix), Q-Fever, QFEVER, QFEVR, QFP, Rickettsial Antibody, Typhus, Weil-Felix
Components
| Code | Name |
|---|---|
| RQFVRR | Q Fever Antibody Screen |
Interpretation
Method
Enzyme-Linked Immunosorbent Assay (ELISA)
Reference Range
See individual components
Ref. Range Notes
Interpretation:
Negative: No antibodies to Q fever (Coxiella burnetii) detected. Repeat testing on a new sample collected in 2 to 3 weeks if acute Q fever is suspected.
Reactive: Not diagnostic. Sample reflexed to the indirect immunofluorescence assay to determine Q fever (Coxiella burnetii) phase I and phase II IgM and IgG titers.
Interferences and Limitations
Cautions: Serologic responses are time dependent. Specimens collected too early in the disease may not have detectable antibody levels. A second specimen collected 2 to 3 weeks may be necessary to detect antibody.
Cross-reactivity may occur with other closely related intracellular organisms (eg, Rickettsia spp).
Guidelines
Ordering & Collection
Specimen Type
Collection
3 mL in GOLD SST or RED TOP tube
Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 7 days; Frozen: 7 Days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen.
Quantity
requested: 0.6 mL serum
minimum: 0.5 mL serum
Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: QFEVR.
- Interfaced: Yes.
Stability: Refrigerated (preferred): 7 days; Frozen: 7 Days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus, heat-inactivated specimen.
Performance
LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories (Superior Drive)
800-533-1710 3050 Superior Drive NW |
|---|
Frequency
Performed: Sunday - Friday. Report Available: 1-4 days from sample receipt.
Available STAT?
No