Path Grand Rounds: Androgenetic-Biparental Mosaicism and the Pathogenesis of Hepatic Mesenchymal Hamartoma

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Raj Kapur, MD, PhD
Seattle Children’s Hospital

Date & Time

March 4, 2015 at 12:00pm - 1:00pm


UWMC, NE110 conference room


Why Attend?

Many conditions presented to the pediatric pathology are rare and have a genetic basis. The chance encounter of two such lesions, placental mesenchymal dysplasia and hepatic mesenchymal hamartoma, in a single patient suggested a common pathogenetic basis, and opportunities to learn more about potential molecular “underpinnings” for these seemingly disparate entities. Learn how a series of investigations, conducted primarily with resources in the clinical laboratory, have helped explain this association and implicated expression of a cluster of evolutionarily new miRNAs in hepatic hamartoma formation.

Reference: PMID: 24555441