Basic Biology of Aging: Werner Syndrome in Japan: From the Medical, Molecular and Social Aspects
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Koutaro Yokote, MD, PhD
Department of Medicine
Chiba University, Japan
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations at the WRN locus. The WRN gene codes for a member of the RecQ family of DNA helicases. A founder WRN mutation and high WS frequency had previously been reported in Japan. Dr. Yokote will discuss clinical approaches to this disorder including ongoing clinical research studies and nationwide efforts to facilitate diagnosis and referral.
The Basic Biology of Aging seminar series is sponsored by The Nathan Shock Center of Excellence in the Basic Biology of Aging, the Genetic Approaches to Aging Training Grant, and the UW Healthy Aging and Longevity (HALo) Research Institute. The seminar features guest speakers presenting the latest research in the basic biology of aging.