Basic Biology of Aging: Aging & Cancer: Rival demons?
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Judith Campisi, PhD
Buck Institute for Research on Aging
Aging & Cancer: Rival demons?
Aging is the largest risk factor for a host of chronic diseases. Why is this so? One widely accepted view holds that one or more basic aging process alters tissues and the systemic milieu, making them vulnerable to loss of homeostasis and pathology. I will discuss the evidence that cellular senescence, a complex stress response that protects multicellular organisms from cancer, is a candidate basic aging process that can drive multiple age-related diseases. These diseases range from neurodegeneration to, ironically, late life cancer. I will also discuss new possibilities for maintaining the anti-cancer benefits of the senescence response while ameliorating its deleterious effects.
The Basic Biology of Aging seminar series is sponsored by The Nathan Shock Center of Excellence in the Basic Biology of Aging, the Genetic Approaches to Aging Training Grant, and the UW Healthy Aging and Longevity (HALo) Research Institute. The seminar features guest speakers presenting the latest research in the basic biology of aging.