Basic Biology of Aging: Nuclear and Mitochondrial mutagenesis: Theoretical and Clinical insights into cancer and aging
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Jason Bielas, PhD
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Nuclear and Mitochondrial mutagenesis: Theoretical and Clinical insights into cancer and aging
Mitochondrial mutations, some conferring pro-tumorigenic potential, are recurrently identified in cancer, though how and why they arise is poorly understood. In the nucleus, clonal mutations may result from selection and expansion of de novo mutations arising from genetic instability. If this trend is recapitulated in mitochondrial DNA (mtDNA), then mtDNA should display a mutator phenotype, i.e. frequent de novo mutations. However, we discovered decreased mtDNA rare point mutations in cancer compared to matched normal tissue. Influenced by these findings, we have re-examined the putative role of mitochondrial mutagenesis in cancer and aging, and highlight its potential as a therapeutic target for cancer treatment.
The Basic Biology of Aging seminar series is sponsored by The Nathan Shock Center of Excellence in the Basic Biology of Aging, the Genetic Approaches to Aging Training Grant, and the UW Healthy Aging and Longevity (HALo) Research Institute. The seminar features guest speakers presenting the latest research in the basic biology of aging.