Pathology Presents: Exploiting viruses to understand and treat cancer
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Clodagh O'Shea, PhD
Salk Insitute for Biological Studies
- Faculty Sponsor
Pathology Graduate Students
Exploiting viruses to understand and treat cancer
The O'Shea lab is employing the help of a small DNA virus, called adenovirus, to both understand and treat cancer. Normally, cellular replication is tightly controlled. However, both DNA viruses and tumor cells sabotage such controls to drive their respective pathological propagation, albeit with one small difference: In tumor cells the key cellular players are targeted via mutations, while in infected cells viral proteins achieve the same end. Not surprisingly, many of the cellular targets are the same.