Pathology Presents: In vivo microscopy for early detection and diagnosis of pulmonary disease
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Lida Hariri, MD, PhD
Instructor, Harvard Medical School
Assistant Pathologist, Massachusetts General Hospital
- Faculty Sponsor
Benjamin Hoch, MD
In vivo microscopy for early detection and diagnosis of pulmonary disease
In vivo microscopy (IVM) provides microscopic visualization of tissues in patients without physical tissue removal. Optical coherence tomography (OCT) is a form of IVM that offers non-destructive, large volume, high resolution imaging using thin optical catheters. My research focuses on investigating bronchoscopic OCT for early detection and diagnosis of lung disease:
1) Lung Cancer - OCT to improve diagnostic yield on small biopsy/FNA by:
a. Guiding biopsy site selection microscopically during procedure to reduce sampling error and increase diagnostic tumor yield
b. Providing large volumetric OCT imaging data sets as a form of “virtual” tissue to accompany physical tissue biopsies for pathology assessment
2) Interstitial Lung Disease - Bronchoscopic OCT for low-risk in vivo microscopic diagnosis of ILD without surgery or physical tissue removal
In this talk, I will discuss the role of OCT in these clinical applications, as well as applications in other organ systems. I will also discuss the potential role of pathologists in implementing and interpreting IVM as part of clinical practice.