Pathology Presents: Disease Modeling and Heart Regeneration with Human Pluripotent Stem Cells
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Charles Murry, MD, PhD
Professor, Department of Pathology
University of Washington
- Faculty Sponsor
Peter Rabinovitch, MD, PhD
Disease Modeling and Heart Regeneration with Human Pluripotent Stem Cells
Heart disease is the number one cause of death worldwide, and its prevalence in the US is increasing as our population ages. Our group uses pluripotent stem cells to derive human cardiomyocytes that can be used for disease modeling, tissue engineering, drug discovery and regenerative medicine. In this lecture I will describe progress in modeling the most common genetic cause of heart failure, dilated cardiomyopathy, using both patient-derived stem cells and genome editing, and describe strategies to enhance cardiomyocyte maturation for the study of adult-onset disease. In the second half, I will review our progress in regenerating the heart with human cardiomyocytes, detailing our recent efforts in nonhuman primates and plans for a clinical trial.