Basic Biology of Aging: Why do Alzheimer’s Disease and Cardiovascular Disease have similar risk factors and protective drugs
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Robert Shmookler Reis, PhD
University of Arkansas for Medical Sciences
Why do Alzheimer’s Disease and Cardiovascular Disease have similar risk factors and protective drugs? Clues from the ‘aggregome’
Alzheimer’s Disease and cardiovascular disease obviously affect different organs, and yet they share some surprising similarities. Risk factors for both include ApoE ε4 (and protection by allele ε2), and inflammatory markers such as complement C3 and cytokines such as IL-1, IL-8 and IL-11. In long-term prospective studies, aspirin and other NSAIDs that protect against cardiovascular disease also confer risk reductions for several neurodegenerative diseases including Alzheimer’s. We have examined the proteomes of specific aggregates that are characteristic and diagnostic of Alzheimer’s disease, and find that aggregates of overlapping composition also accumulate in the mouse heart during normal aging and during hypertension induced by angiotensin-2. The nature of these shared proteins and their post-translational modifications suggest mechanisms for current and future therapeutics.
The Basic Biology of Aging seminar series is sponsored by The Nathan Shock Center of Excellence in the Basic Biology of Aging, the Genetic Approaches to Aging Training Grant, and the UW Healthy Aging and Longevity (HALo) Research Institute. The seminar features guest speakers presenting the latest research in the basic biology of aging.