Annual Alvord Lecture: Imaging approaches to understand the role of CD2AP in kidney and Alzheimer's disease
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Andrey S. Shaw, MD
- Faculty Sponsor
C. Dirk Keene, MD, PhD
"Imaging approaches to understand the role of CD2AP in kidney and Alzheimer's disease"
Dr. Shaw cloned CD2AP as a protein involved in the Immunological Synapse. Surprisingly, mouse knockout studies showed that CD2AP plays an important role in the kidney podocyte and human genetics studies implicate CD2AP as a susceptibility gene in Alzheimers. The exact role of CD2AP is not known. The Shaw lab has been using a variety of imaging approaches including intravital 2 photon microscopy as well as lattice light sheet microscopy as well as proteomic studies to understand the basic mechanism of CD2AP function to try and understand its relevance in kidney and Alzheimer diseases
The Alvord Lecture honors and recognizes Emeritus Professor Ellsworth Alvord as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington for 42 years from 1960 to 2002.