Russell Ross Endowed Lectureship: Monocyte Heterogeneity in Atherosclerosis
This event has ended.
Catherine C. Hedrick, PhD
Division of Inflammation Biology
La Jolla Institute for Immunology
- Faculty Sponsor
Michael Rosenfeld, PhD
Monocytes are innate immune cells that are quick responders to endothelial dysfunction that initiates atherosclerotic plaque development. Many studies have shown that monocytes are recruited by the damaged endothelium to the vessel wall, where the monocytes are exposed to oxidized lipids and cytokines and differentiate into macrophages. We now know that all monocytes are not the same. There is heterogeneity in blood monocytes that gives rise to different monocyte functions. We will discuss this heterogeneity and how it impacts cardiovascular disease.
A special seminar dedicated to the memory and scientific legacy of Russell Ross, Professor and Chair, Department of Pathology, 1982-1994