Pathology Presents: Dr. Lillian Siu
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Speaker
Lillian L. Siu, MD
Professor
BMO Chair in Precision Genomics
University of Toronto
- Faculty Sponsor
Student: Nandita Kumar
- Date & Time
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October 28, 2020 at 1:30pm - 2:30pm
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Description
Lillian L. Siu, MD
BMO Chair in Precision Genomics
Professor of Medicine, Princess Margaret Cancer Centre, Toronto, Canada
"Translational Research to Identify Predictive Biomarkers for Immunotherapy"
Immunotherapy especially checkpoint inhibitors such as antibodies directed against the programmed death protein and its ligand (anti-PD1 and anti-PD-L1 antibodies) have changed the treatment paradigm of many cancers, including head and neck cancer. However, biomarkers to identify those who may benefit from checkpoint inhibitors have been limited to PD-L1 status by immunohistochemistry and tumor mutational burden by next generation sequencing. In this seminar, several non-invasive biomarkers, including liquid biopsy to quantify circulating tumor DNA (ctDNA) (Bratman et al. Nat Cancer 2020), microbiome assessments to determine the effects of oral and gut microbiota, and also radiomic evaluations of conventional radiological imaging, to determine if these multi-omic biomarkers may off additional insights on patient selection for immunotherapy.