Path Grand Rounds: Dr. Peter Nelson

Speaker

Peter Nelson, MD
Member, Divisions of Human Biology and Clinical Research, Fred Hutch
Professor, Division of Oncology, UW School of Medicine

Faculty Sponsor

Larry True


Date & Time

December 2, 2020 at 1:30pm - 2:30pm

Location

Online Meeting


Description

Peter Nelson, MD

Member, Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center

Professor, Division of Oncology, UW School of Medicine

 

“Determining Inter- and Intra-Tumor Heterogeneity of Molecular Phenotypes by Digital Spatial Profiling of Transcripts and Proteins”

 

Cancers are recognized to comprise complex environments of diverse tumor cells and host microenvironment components. Metastatic prostate cancer demonstrates this complexity with multiple distinct genotypes and molecular phenotypes that reflect inherent biology, metastatic sites of dissemination, and the responses to treatment pressures. While inter-individual heterogeneity serves as the backbone of precision medicine/oncology, intra-individual and intra-tumor heterogeneity has the potential to drive treatment resistance. Developing an understanding of tumor complexity is enabled by technological advances such as digital spatial profiling for comprehensively assessing the tumor and host characteristics that drive tumor behavior and categorize patients for optimizing treatment plans.

 

After viewing this lecture, attendees should be able to:

1) Understand the molecular diversity of metastatic prostate cancer.

2) Understand the importance of tumor subtyping in the context of therapy.

3) Describe the role of spatial profiling in assessing tumor heterogeneity.