Pathology Presents: Dr. Oksana Berezovska

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Oksana Berezovska, PhD
Associate Professor
Harvard Medical School

Faculty Sponsor

Student: Allison Knupp

Date & Time

January 27, 2021 at 1:30pm - 2:30pm


Online Meeting


Oksana Berezovska, PhD

Associate Professor of Neurology

Harvard Medical School


"The role of PS1/gamma-secretase in the pathophysiology of Alzheimer’s disease”


Presenilin (PS)/γ-secretase is widely recognized as the protease responsible for the processing of APP and thus for production of neurotoxic β-amyloid (Aβ) peptides in Alzheimer’s disease (AD). However, it also cleaves ~150 other substrates and has multiple interacting partners, thereby influencing numerous cellular signaling pathways that could contribute to AD pathogenesis. This may partially explain why Aβ-targeting therapies failed in clinical trials. This seminar will review “the other side” of the PS/gamma-secretase. We will also discuss molecular imaging approaches and tools, and how these may be helpful in developing new therapeutic strategies for neurodegenerative disorders.