-
Pathology Presents
4:30 pm - 5:30 pm
Modeling Renal Pathophysiology with Human Kidney Organoids Derived from Pluripotent Stem Cells
Benjamin Freedman, PhD, Assistant Professor of Medicine, Division of Nephrology, Department of Medicine, University of Washington
Location: Health Sciences Building, T-739
Summary: Organoids are multicellular units in vitro that resemble a tissue or organ of the body. Recently, we have generated kidney organoids for the first time, starting with human pluripotent stem cells. Kidney organoids include proximal tubules, distal tubules, and podocytes in nephron-like segments, recapitulating key architectural features of human tissue. Using the CRISPR-Cas gene editing system, we have further generated mutant organoids that express phenotypes of glomerular disease and polycystic kidney disease in vitro. Organoids raise new possibilities for understanding human disease at the cellular level for diagnostic and therapeutic applications.
Conference Schedule - MEDHUB
A current list of all events within the Residency Program can be found in MedHub.
Showing events for the
Pathology Presents
calendar.
Show all events for this date range.
All Events
Annual Alvord Lecture
Basic Biology of Aging
Doctoral Dissertations
Earl P. Benditt Endowed Lectureship
Genetic Approaches to Aging Trainee Research Presentations
Lab Med Grand Rounds
Lab Med Research Conference
Path Grand Rounds
Pathology Presents
Pathology Retreat
Russell Ross Endowed Lectureship
Seminars