Yajuan J. Liu, PhD, FACMG

Professor | DIRECTOR, CLINICAL GENOMICS AND CYTOGENETICS LABORATORIES | PROGRAM DIRECTOR, LABORATORY GENETICS AND GENOMICS

Yajuan J. Liu, PhD, FACMG

Pronouns:

She, her

E-mail:

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Office Location:

HSB - Room - H474-B

Mailing Address:

Box 357470
1959 NE Pacific St.
Seattle, WA 98195


Clinical and Research Background

Dr. Liu’s clinical specialties are clinical molecular genetics and clinical cytogenetics and genomics (ABMGG) for both constitutional genetic disorders in prenatal and postnatal settings and acquired genetic disorders
including solid tumors and hematological neoplasms. Dr. Liu’s research interest is in translational medicine using genomic approaches to aid the understanding of the genetic and molecular etiologies of human diseases. Projects in Dr. Liu’s laboratory currently include:
(1) Implementing novel cytogenetics and genomics approaches to characterize numerical and structural chromosomal aberrations, copy number alterations, and copy neutral absence/loss of heterozygosity in human diseases using next generation sequencing solutions (such as Hi-C/3D whole genome sequencing, long-read sequencing) and optical genome mapping (OGM).
(2) Using RNA-seq and Hi-C sequencing to characterize gene fusions and juxtapositions in cancer, especially novel fusions in sarcoma.
(3) Implementing genome-wide methylation profiling in cancer diagnostics (such as CNS tumors, sarcoma, renal cell carcinoma, and etc).
(4) Using multi-omics assays to characterize genetic mutations and their functional consequences to understand disease etiology.
The main goals are to develop molecular and genetic diagnostics using both conventional and novel genetics and genomic approaches for personalized care.
Dr. Liu is the Program Director of Laboratory Genetics and Genomics (LGG) Fellowship, and also involved in the training of medical residents and fellows and at the University of Washington School of Medicine.

Clinical Genomics Laboratory

Cytogenetics Laboratory

Board Certifications

Clinical Molecular Genetics, American Board of Medical Genetics and Genomics

Clinical Cytogenetics, American Board of Medical Genetics and Genomics

Academic and Medical Appointments

Professor, Department of Laboratory Medicine and Pathology,University of Washington School of Medicine, Seattle, WA. 2022-present

Associate Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA. 2016-2022

Assistant Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA. 2009-2016

Director (founding director), Clinical Genomics Laboratory, Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA. 2009-present.

Director of Cytogenetics Laboratory, University of Washington Medical Center, Seattle, WA. 2020-present

Co-Director of Cytogenetics Laboratory, University of Washington Medical Center, Seattle, WA, 2009-2020

Senior Research Scientist, Departments of Biology and Genome Sciences, University of Washington, Seattle, WA, 2002-2007

Education and Training

Clinical Molecular Genetics Fellow, Department of Medicine, University of Washington, Seattle, WA, 2012-2013

Postdoctoral Fellow, Cancer Genetics, Department of Medicine, University of Washington, Seattle, WA, 2007-2009

Clinical Cytogenetics Fellow, Department of Medicine, University of Washington, Seattle, WA, 2007-2009

Postdoctoral Fellow, Yeast Genetics and Molecular Evolution. Departments of Biology and Genome Sciences, University of Washington, Seattle, WA, 1995-2002

State University of New York, College of Environmental Science & Forestry, Syracuse, NY, Molecular Biology, Ph.D., 1995

Wuhan University, Hubei, China, Genetics, Master of Science, 1989

Wuhan University, Hubei, China, Cell Biology, Bachelor of Science, 1986

Publications

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