Clinical and Research Background
Regulation of Fibroblast growth and Matrix synthesis during inflammation
For many years, we have been studying the extracellular matrix (ECM) particularly in two acquired diseases: chronic inflammation and fibrosis.
Fibroblasts are the major cell type responsible for ECM production in most connective tissues, and our laboratory has been studying the regulation of fibroblast growth and its ECM production by various cytokines and growth factors. Using the human idiopathic pulmonary fibrosis and chronic periodontitis as models for fibrosis and chronic inflammation, respectively, we are studying the importance of fibroblast subpopulations and local environment of the ECM in diseases and wound healing. We are attempting to define specific interactions between ECM components and fibroblasts and elucidate the biochemical signaling reactions that determine these interactions.
Academic and Medical Appointments
Professor Emeritus, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2013-Present
Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA, 2004-2013
Adjunct Professor, Oral Biology, University of Washington School of Medicine, Seattle, WA, Present
Research Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA , 1986-2004
Research Associate Professor, Department of Pathology, University of Washington School of Medicine, Seattle, WA , 1978-1986
Education and Training
National Institute of Dental Research Visiting Fellowship, 1969-1971
Postdoctoral Fellowship, Department of Pathology, University of Toronto, Toronto, ON, 1969
Medical Research Council Postdoctoral Fellowship, Department of Biochemistry, University of Toronto, Toronto, ON, 1967-1969
Council of Scientific and Industrial Research Fellowship, University of Madras Biochemistry Laboratory, Madras, India, 1963-1965
Doctorate of Philosophy, University of Madras, India, 1967
Master of Science, University of Madras, India, 1963
Bachelor of Science, University of Madras, India, 1961
Publications
Latest publications from PubMed