Digital Slide Database

Welcome to the University of Washington Department of Laboratory Medicine and Pathology BRaIN Lab Digital Slide Database. Our database contains over one-hundred-thousand scanned human brain slide images organized by case number. The slides were almost entirely scanned on an Aperio AT2 or Aperio GT450 and are stored as .svs files. The cases are bucketed by thousands for human-usability. The slides are labeled by case number, region, stain, and date scanned. Slide labels are censored or removed to avoid having any donor-identifying information.

Additional information on regions, stains, and slides is coming soon.

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Publications

Selmanovic E, Gibbons LE, Folkerth RD, Keene CD, Nolan A, Crane P, Postupna N, Lee CS, Latimer CS, Ariza-Torres J, Hof PR, Dams-O'Connor K. Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study. J Alzheimers Dis. 2026 Jun 16:13872877261457138. doi: 10.1177/13872877261457138. Epub ahead of print. PMID: 42300698; PMCID: PMC13309140.
Latimer C, Lorenzo-Betancor O, Chen DH, Su K, Bogdani M, Park AJ, Kim M, Weiss J, Callier M, Chiu EH, Fish S, Witt JL, Raskind WH, Davis MY, Keene CD, Zabetian CP. Heterogenous Neuropathology in a Pedigree with RAB39B-Related Parkinson's Disease. Mov Disord. 2026 May 15. doi: 10.1002/mds.70341. Epub ahead of print. PMID: 42138034.
Alsulami A, Bogdani M, MacLean E, Keene CD, McGrath S; Dog Aging Project Consortium; Latimer CS, Moreno JA. Alzheimer's Disease Neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function. Res Sq [Preprint]. 2026 Mar 3:rs.3.rs-8994620. doi: 10.21203/rs.3.rs-8994620/v1. PMID: 41836504; PMCID: PMC12980377.
Gray SL, Yu O, Gatto NM, Marcum ZA, Latimer CS, Postupna N, Su YR, Barthold D, van Dalen JW, Richard E, Keene CD, Shaw PA, McEvoy LK, Larson EB, Crane PK. Angiotensin II-Stimulating Antihypertensive Medications and Dementia-Related Neuropathology. JAMA Netw Open. 2026 Feb 2;9(2):e2559113. doi: 10.1001/jamanetworkopen.2025.59113. PMID: 41670993; PMCID: PMC12895290.
Ogg J, Postupna N, Gibbons LE, Ariza J, Xiao M, Fonseca LM, Jayadev S, Keene CD, Bird TD, Latimer CS. Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer's disease. Acta Neuropathol. 2025 Sep 4;150(1):24. doi: 10.1007/s00401-025-02931-1. PMID: 40906048; PMCID: PMC12411319.
Trivedi P, Forrest K, Fisher DW, Winstone JK, McMillan PJ, Valentine M, Postupna N, Wilson A, Bajwa T, MacCoss MJ, Keene CD, Darvas M, Kraemer BC, Hoofnagle AN, Latimer CS. Performance of novel tau antibodies across multiple modalities for Alzheimer's disease assessment. Alzheimers Dement. 2025 Jul;21(7):e70481. doi: 10.1002/alz.70481. PMID: 40684247; PMCID: PMC12276073.
Barsoum S, Latimer CS, Nolan AL, Barrett A, Chang K, Troncoso JC, Keene CD, Benjamini D. Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer's disease. Brain Commun. 2025 Jun 18;7(3):fcaf245. doi: 10.1093/braincomms/fcaf245. PMID: 40585810; PMCID: PMC12203664.
Feichtenbiner AB, Sytsma K, O'Boyle RP, Mittenzwei R, Maioli H, Scherpelz KP, Child DD, Li N, Ariza Torres J, Keene L, Kirkland A, Howard K, Latimer C, Keene CD, Ransom C, Nolan AL. Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability. J Neuroinflammation. 2025 Jan 16;22(1):9. doi: 10.1186/s12974-024-03328-9. PMID: 39819341; PMCID: PMC11740464.
Samstag CL, Chapman NH, Gibbons LE, Geller J, Loeb N, Dharap S, Yagi M, Cook DG, Pagulayan KF, Crane PK, Larson EB, Wijsman EM, Latimer CS, Bird TD, Keene CD, Carlson ES. Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease. Alzheimers Dement. 2025 Feb;21(2):e14428. doi: 10.1002/alz.14428. Epub 2024 Dec 23. PMID: 39713867; PMCID: PMC11848203.
Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Agrawal A, Kana O, Zhen X, Barlow ST, Brouner K, Campos J, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Cool J, Dalley R, Darvas M, Ding SL, Dolbeare T, Egdorf T, Esposito L, Ferrer R, Fleckenstein LE, Gala R, Gary A, Gelfand E, Gloe J, Guilford N, Guzman J, Hirschstein D, Ho W, Hupp M, Jarsky T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore MD, Kirkland A, Kunst M, Lee BR, Leytze M, Mac Donald CL, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Mena G, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus JK, Olsen PA, Pacleb M, Pagan CM, Peña N, Pham T, Pom CA, Postupna N, Rimorin C, Ruiz A, Saldi GA, Schantz AM, Shapovalova NV, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting JT, Torkelson A, Tran T, Valera Cuevas NJ, Walling-Bell S, Wang MQ, Waters J, Wilson AM, Xiao M, Haynor D, Gatto NM, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith KA, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES. Integrated multimodal cell atlas of Alzheimer's disease. Nat Neurosci. 2024 Dec;27(12):2366-2383. doi: 10.1038/s41593-024-01774-5. Epub 2024 Oct 14. PMID: 39402379; PMCID: PMC11614693.

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