Publications

Select Publications

• Ogg J, Postupna N, Gibbons LE, Ariza J, Xiao M, Fonseca LM, et al. Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer's disease. Acta Neuropathol 2025 Sep 4; 150(1):24. doi:10.1007/s00401-025-02931-1. Pubmed PMID: 40906048
• Trivedi P, Forrest K, Fisher DW, Winstone JK, McMillan PJ, Valentine M, Postupna N, Wilson A, Bajwa T, MacCoss MJ, Keene CD, Darvas M, Kraemer BC, Hoofnagle AN, Latimer CS. Performance of novel tau antibodies across multiple modalities for Alzheimer's disease assessment. Alzheimers Dement. 2025 Jul;21(7):e70481. doi: 10.1002/alz.70481. PubMed PMID: 40684247; PubMed Central PMCID: PMC12276073.
• Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Agrawal A, Kana O, Zhen X, Barlow ST, Brouner K, Campos J, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Cool J, Dalley R, Darvas M, Ding SL, Dolbeare T, Egdorf T, Esposito L, Ferrer R, Fleckenstein LE, Gala R, Gary A, Gelfand E, Gloe J, Guilford N, Guzman J, Hirschstein D, Ho W, Hupp M, Jarsky T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore MD, Kirkland A, Kunst M, Lee BR, Leytze M, Mac Donald CL, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Mena G, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus JK, Olsen PA, Pacleb M, Pagan CM, Peña N, Pham T, Pom CA, Postupna N, Rimorin C, Ruiz A, Saldi GA, Schantz AM, Shapovalova NV, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting JT, Torkelson A, Tran T, Valera Cuevas NJ, Walling-Bell S, Wang MQ, Waters J, Wilson AM, Xiao M, Haynor D, Gatto NM, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith KA, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES. Integrated multimodal cell atlas of Alzheimer's disease. Nat Neurosci. 2024 Dec;27(12):2366-2383. doi: 10.1038/s41593-024-01774-5. Epub 2024 Oct 14. PubMed PMID: 39402379; PubMed Central PMCID: PMC11614693.
• Latimer CS, Prater KE, Postupna N, Dirk Keene C. Resistance and Resilience to Alzheimer's Disease. Cold Spring Harb Perspect Med. 2024 Aug 1;14(8). doi: 10.1101/cshperspect.a041201. Review. PubMed PMID: 38151325; PubMed Central PMCID: PMC11293546.
• Jadhav VS, Stair JG, Eck RJ, Smukowski SN, Currey HN, Toscano LG, Hincks JC, Latimer CS, Valdmanis PN, Kraemer BC, Liachko NF. Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets. Neurobiol Dis. 2024 Apr;193:106441. doi: 10.1016/j.nbd.2024.106441. Epub 2024 Feb 18. PubMed PMID: 38378122; PubMed Central PMCID: PMC11059213.
• Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, William-Ramirez J, Herisse R, Deden-Binder LJ, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, Connors TR, Oakley DH, Frosch MP, Young SI, Van Leemput K, Dalca AV, FIschl B, Mac Donald CL, Keene CD, Hyman BT, Iglesias JE. Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. bioRxiv. 2024 Jan 30;. doi: 10.1101/2023.06.08.544050. PubMed PMID: 37333251; PubMed Central PMCID: PMC10274889.
• Fazeli E, Child DD, Bucks SA, Stovarsky M, Edwards G, Rose SE, Yu CE, Latimer C, Kitago Y, Bird T, Jayadev S, Andersen OM, Young JE. A familial missense variant in the Alzheimer's disease gene SORL1 impairs its maturation and endosomal sorting. Acta Neuropathol. 2024 Jan 20;147(1):20. doi: 10.1007/s00401-023-02670-1. PubMed PMID: 38244079; PubMed Central PMCID: PMC10799806.
• Cholerton B, Latimer CS, Crane PK, Corrada MM, Gibbons LE, Larson EB, Kawas CH, Keene CD, Montine TJ. Neuropathologic Burden and Dementia in Nonagenarians and Centenarians: Comparison of 2 Community-Based Cohorts. Neurology. 2024 Feb 13;102(3):e208060. doi: 10.1212/WNL.0000000000208060. Epub 2024 Jan 4. PubMed PMID: 38175995; PubMed Central PMCID: PMC1109777. 
• Maioli H, Mittenzwei R, Shofer JB, Scherpelz KP, Marshall D, Nolan AL, Nelson PT, Keene CD, Latimer CS. Performance of a condensed protocol to assess limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. J Neuropathol Exp Neurol. 2023 Jun 20;82(7):611-619. doi: 10.1093/jnen/nlad035. PubMed PMID: 37195467; PubMed Central PMCID: PMC10280345.
• Latimer CS, Melief EJ, Ariza-Torres J, Howard K, Keen AR, Keene LM, Schantz AM, Sytsma TM, Wilson AM, Grabowski TJ, Darvas M, O'Connor KD, Nolan AL, Edlow BL, Mac Donald CL, Keene CD. Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue. Methods Mol Biol. 2023;2561:3-30. doi: 10.1007/978-1-0716-2655-9_1. PubMed PMID: 36399262.
• Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG, Leverenz JB, Latimer CS, Mackenzie IR, Mao Q, McAleese KE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye KE, Teich AF, Thal DR, Tomé SO, Troncoso JC, Wang SJ, White CL 3rd, Wisniewski T, Yang HS, Schneider JA, Dickson DW, Neumann M. LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol. 2023 Feb;145(2):159-173. doi: 10.1007/s00401-022-02524-2. Epub 2022 Dec 13. PubMed PMID: 36512061; PubMed Central PMCID: PMC9849315.
• Nelson PT, Brayne C, Flanagan ME, Abner EL, Agrawal S, Attems J, Castellani RJ, Corrada MM, Cykowski MD, Di J, Dickson DW, Dugger BN, Ervin JF, Fleming J, Graff-Radford J, Grinberg LT, Hokkanen SRK, Hunter S, Kapasi A, Kawas CH, Keage HAD, Keene CD, Kero M, Knopman DS, Kouri N, Kovacs GG, Labuzan SA, Larson EB, Latimer CS, Leite REP, Matchett BJ, Matthews FE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Nelson RS, Neltner JH, Nguyen AT, Petersen RC, Polvikoski T, Reichard RR, Rodriguez RD, Suemoto CK, Wang SJ, Wharton SB, White L, Schneider JA. Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathol. 2022 Jul;144(1):27-44. doi: 10.1007/s00401-022-02444-1. Epub 2022 Jun 13. PubMed PMID: 35697880; PubMed Central PMCID: PMC9552938.
• Latimer CS, Stair JG, Hincks JC, Currey HN, Bird TD, Keene CD, Kraemer BC, Liachko NF. TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans. Dis Model Mech. 2022 Apr 1;15(4). doi: 10.1242/dmm.049323. Epub 2022 Apr 27. PubMed PMID: 35178571; PubMed Central PMCID: PMC9066518.
• Lee CS, Latimer CS, Henriksen JC, Blazes M, Larson EB, Crane PK, Keene CD, Lee AY. Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain Pathol. 2021 Nov;31(6):e12974. doi: 10.1111/bpa.12974. Epub 2021 May 19. PubMed PMID: 34009663; PubMed Central PMCID: PMC8549025.
• Latimer CS, Lucot KL, Keene CD, Cholerton B, Montine TJ. Genetic Insights into Alzheimer's Disease. Annu Rev Pathol. 2021 Jan 24;16:351-376. doi: 10.1146/annurev-pathmechdis-012419-032551. Review. PubMed PMID: 33497263; PubMed Central PMCID: PMC8664069.
• Webster JM, Grabowski TJ, Madhyastha TM, Gibbons LE, Keene CD, Latimer CS. Leveraging Neuroimaging Tools to Assess Precision and Accuracy in an Alzheimer's Disease Neuropathologic Sampling Protocol. Front Neurosci. 2021;15:693242. doi: 10.3389/fnins.2021.693242. eCollection 2021. PubMed PMID: 34483821; PubMed Central PMCID: PMC8416420.
• Latimer CS, Burke BT, Liachko NF, Currey HN, Kilgore MD, Gibbons LE, Henriksen J, Darvas M, Domoto-Reilly K, Jayadev S, Grabowski TJ, Crane PK, Larson EB, Kraemer BC, Bird TD, Keene CD. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019 Jun 7;7(1):91. doi: 10.1186/s40478-019-0743-1. PubMed PMID: 31174609; PubMed Central PMCID: PMC6556006.
• Latimer CS, Shively CA, Keene CD, Jorgensen MJ, Andrews RN, Register TC, Montine TJ, Wilson AM, Neth BJ, Mintz A, Maldjian JA, Whitlow CT, Kaplan JR, Craft S. A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis. Alzheimers Dement. 2019 Jan;15(1):93-105. doi: 10.1016/j.jalz.2018.06.3057. Epub 2018 Nov 19. PubMed PMID: 30467082; PubMed Central PMCID: PMC6383152.
• Flanagan ME, Cholerton B, Latimer CS, Hemmy LS, Edland SD, Montine KS, White LR, Montine TJ. TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. J Alzheimers Dis. 2018;66(4):1549-1558. doi: 10.3233/JAD-180162. PubMed PMID: 30452409; PubMed Central PMCID: PMC6382067.
• Latimer CS, Keene CD, Flanagan ME, Hemmy LS, Lim KO, White LR, Montine KS, Montine TJ. Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies. J Neuropathol Exp Neurol. 2017 Jun 1;76(6):458-466. doi: 10.1093/jnen/nlx030. PubMed PMID: 28499012; PubMed Central PMCID: PMC6334750.

   

  Link to Bibliography: https://www-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/myncbi/caitlin.latimer.1/bibliography/public/