The Stewart/Shi lab is a collaborative environment, pooling resources to better understand Parkinson’s disease (PD), Alzheimer’s disease (AD), and other types of neurodegeneration. We are particularly interested in identifying biomarkers for neurodegenerative diseases, especially novel markers to improve discrimination between related diseases, better reflect ongoing disease processes, and decrease the burden of monitoring on patients. We enjoy using a wide variety of state-of-the-art platforms to examine processes involved in neurodegeneration from the molecular level, to animal models, to tissues and biofluids from human patients.


  • June 2020, Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction
    • ​In a recent study, we demonstrate that microvesicles derived from oligodendrocytes – and carrying α-synuclein – are less abundant in the peripheral blood of multiple system atrophy patients and a mouse model compared to controls. [read more...
  • February 2020, Dr. Jing Zhang, the founding PI of this lab, retired from the UW
    • After close to 20 years of clinical service, continuous extra mural research funding, hundreds of publications, and countless trainees and collaborators, JZ, as he was affectionately called, retired from the UW. [read more...]