Clues to the diagnosis of dysplasia

Areas with mucin depletion:

Lower power view will allow detection of areas with mucin depletion.

Areas with abundant mucin production:

Areas involved by Barrett's metaplastic epithelium with abundant mucin production should alert the pathologist to look carefully for dysplastic nuclei.

The hypermucinous areas may resemble colonic mucosa.  Based on the nuclear features, a diagnosis of "indefinite for dysplasia" or "low-grade dysplasia" may be warranted in this case.