Department of Laboratory Medicine & Pathology, UW Medicine, University of Washington

As of July 1, 2020, the Departments of Laboratory Medicine and Pathology have merged to form the Department of Laboratory Medicine & Pathology. Find information about our Anatomic Pathology services on this site, or find information about our Clinical Pathology services here.

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  • Educational Resources
    • Images in Pathology
    • Barrett's Esophagus
      • Definition of Barrett’s Esophagus
      • Definition and Characteristics of Dysplasia in Barrett’s Esophagus
        • Images of Barrett's Esophagus Negative for Dysplasia
        • Images of Barrett's esophagus Indefinite for Dysplasia
        • Images of Barrett's esophagus with Low-grade Dysplasia
        • Phenotypes of dysplasia in Barrett's esophagus
        • Clues to the diagnosis of dysplasia
        • Images of Barrett's esophagus with High-grade Dysplasia
        • Images of Barrett's esophagus with Intramucosal adenocarcinoma
      • Pitfalls in the Diagnosis of Dysplasia
      • Problems with Grading of Dysplasia in Barrett’s Esophagus
    • Cytogenetics Gallery

Images of Barrett’s esophagus with High-grade Dysplasia

Diagnosing high-grade dysplasia is very important as many invasive procedures are initiated based on this diagnosis. We like to see loss of nuclear polarity ("rounding up" of nuclei) before making this diagnosis.

Low power view of disortion of crypt architecture.

The most important feature we look for: loss of nuclear polarity

Additional examples we would interpret as high-grade dysplasia.

Dept. of Laboratory Medicine & Pathology
1959 NE Pacific St
Box 357470
Seattle, WA 98195

P: 206-543-1140
F: 206-543-3644
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