Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum (Sendout)
General Information
Lab Name
Lab Code
1086
External Test Id
MDS2
Description
Useful For: Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, brainstem encephalitis, chorea, dyskinesias, myoclonus, and parkinsonism using serum specimens. Refer to Autoimmune Encephalitis Testing Recommendations for additional ordering guidance.
Testing Algorithm: Reflex testing may be performed at additional charge. Refer to Mayo's algorithm below.
Patient Preparation:
- For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
- This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.
Ordering Requirements: Laboratory Medicine Resident (LMR) approval is required.
Synonyms
Adaptor Protein 3 Beta2 Antibody, AGNA-1, AMPA-R Antibody CBA, Amphiphysin Antibody, ANNA-1, ANNA-2, ANNA-3, Anti-Glial Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 1, Anti-Neuronal Nuclear Antibody Type 2, Anti-Neuronal Nuclear Antibody Type 3, AP3B2 IFA, Ataxia, Brainstem encephalitis, CASPR2 IgG CBA, Chorea, Collapsin Response-Mediator Protein-5 IgG Western Blot, Contactin-Associated Protein-Like-2 IgG, CRMP-5 IgG Western Blot, Dipeptidyl Aminopeptidase-Like Protein 6, DPPX Antibody CBA, Dyskinesias, GABA-B-R Antibody CBA, GAD65 Antibody Assay, Gamma Aminobutyric Acid Receptor Type B, GFAP IFA, Glial Fibrillary Acidic Protein Antibody, Glutamic Acid Decarboxylase Antibody, GRAF1 IFA, GTPase regulator associated with focal adhesion kinase-1, IgLON Family Member 5 Antibody, IgLON5 CBA, ITPR1 IFA, Kelch-Like Protein 11 Antibody, KLHL11 Ab CBA, Leucine-Rich Glioma Inactivated Protein-1 IgG, LGI1 IgG CBA, MDS2, Metabotropic Glutamate Receptor 1 Antibody, mGluR1 Ab IFA, Movement Disorder Autoimmune Paraneoplastic Evaluation, Myoclonus, N-methyl-D-Aspartate Receptor Antibody, Neurochondrin IFA, Neuronal Intermediate Filament Antibody, NIF IFA, NMDA-R Ab CBA, P/Q-Type Calcium Channel Antibody, Parkinsonism, PCA-1, PCA-2, PCA-Tr, PDE10A Ab IFA, Phosphodiesterase 10A Antibody, Purkinje Cell Cytoplasmic Antibody Type 1, Purkinje Cell Cytoplasmic Antibody Type 2, Purkinje Cell Cytoplasmic Antibody Type Tr, Septin-5 IFA, Septin-7 IFA, TRIM46 Ab IFA, Tripartite Motif-containing Protein 46 Antibody
Interpretation
Method
Panel and reflex tests include the following methods: Indirect Immunofluorescence Assay (IFA), Cell Binding Assay (CBA), Radioimmunoassay (RIA), Immunoblot (IB), Western Blot (WB)
Ref. Range Notes
Reference Values:
| Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor (AMPA-R) Antibody CBA: | Negative |
| Amphiphysin Antibody: | Negative |
| Anti-Glial Nuclear Antibody Type 1 (AGNA-1): | Negative |
| Anti-Neuronal Nuclear Antibody Type 1 (ANNA-1): | Negative |
| Anti-Neuronal Nuclear Antibody Type 2 (ANNA-2): | Negative |
| Anti-Neuronal Nuclear Antibody Type 3 (ANNA-3): | Negative |
| Adaptor Protein 3 Beta2 (AP3B2) Antibody IFA: | Negative |
| Contactin-Associated Protein-Like-2 (CASPR2) IgG Antibody CBA: | Negative |
| Collapsin Response-Mediator Protein-5 (CRMP-5) IgG WB: | Negative |
| Dipeptidyl Aminopeptidase-Like Protein 6 (DPPX) Antibody CBA: | Negative |
| Gamma Aminobutyric Acid Receptor Type B (GABA-B-R) Antibody CBA: | Negative |
| Glutamic Acid Decarboxylase (GAD65) Antibody Assay: | < or =0.02 nmol/L |
| Glial Fibrillary Acidic Protein (GFAP) Antibody IFA: | Negative |
| GTPase regulator associated with focal adhesion kinase-1 (GRAF1) IFA: | Negative |
| IgLON Family Member 5 (IgLON5) Antibody CBA: | Negative |
| Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) Antibody IFA: | Negative |
| Kelch-Like Protein 11 (KLHL11) Antibody CBA: | Negative |
| Leucine-Rich Glioma Inactivated Protein-1 IgG (LGI1) Antibody CBA: | Negative |
| Metabotropic Glutamate Receptor 1 (mGluR1) Antibody IFA: | Negative |
| Neurochondrin Antibody IFA: | Negative |
| Neuronal Intermediate Filament (NIF) Antibody IFA: | Negative |
| N-methyl-D-Aspartate Receptor (NMDA-R) Antibody CBA: | Negative |
| P/Q-Type Calcium Channel Antibody: | Negative |
| Purkinje Cell Cytoplasmic Antibody Type Tr (PCA-Tr): | Negative |
| Purkinje Cell Cytoplasmic Antibody Type 1 (PCA-1): | Negative |
| Purkinje Cell Cytoplasmic Antibody Type 2 (PCA-2): | Negative |
| Phosphodiesterase 10A (PDE10A) Antibody IFA: | Negative |
| Septin-5 Antibody IFA: | Negative |
| Septin-7 Antibody IFA: | Negative |
| Tripartite Motif-containing Protein 46 (TRIM46) Antibody IFA: | Negative |
Note: Includes reference values for panel tests only.
Interpretation: A positive antibody result is consistent with a diagnosis of an autoimmune movement disorder. A search for cancer may be indicated, depending on the antibody profile. A trial of immune therapy may bring about improvement in neurological symptoms.
Interferences and Limitations
Cautions:
A negative antibody test result does not exclude an autoimmune movement disorder.
Corticosteroid treatment prior to the serum collection may cause a false-negative result.
Intravenous immunoglobulin (IVIg) treatment prior to the serum collection may cause a false-positive result.
Guidelines
Ordering & Collection
Specimen Type
Collection
Collect 12 mL blood in RED TOP tube or GOLD SST
Approval Required
Laboratory Medicine Resident (LMR) approval is required.
Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Quantity
requested: 4 mL serum
minimum: 3 mL serum
Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Login: SEND1-;REFRIG
- RSNDT1: MAYO
- RSTYP1: SRM
- RTSRQ1: ;Movement Disorder, Autoimmune Paraneoplastic Eval, Serum (Mayo Test MDS2)
Sendouts:
- Order Mayo Test: MDS2.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Performance
LIS Dept Code
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories
800-533-1710 200 First Street Southwest |
|---|
Frequency
Performed: Monday - Sunday. Report Available: 8 - 12 days.
Available STAT?
No
Billing & Coding
CPT codes
Billing Comments
CPTs: 86596, 86255x26, 84182, 86341, 0432U
- Note: Includes panel tests only. Reflex testing may be added at additional charge.
LOINC