Chlamydia Serology, IgM & IgG (Sendout)
General Information
Lab Name
Chlamydia Serology, IgM & IgG (Sendout)
Lab Code
RCLAMS
Epic Name
Chlamydia Serology, IgM & IgG (Sendout)
External Test Id
CHLAP
Description
Useful For: Aiding in the diagnosis of Chlamydia pneumoniae or Chlamydia psittaci infection.
References
- Mayo Clinical & Interpretive Information: Chlamydia IgM and IgG Panel, Immunofluorescence, Serum
Synonyms
Bedsonia, Chlamydia Antibodies, Chlamydia pneumoniae (TWAR), Chlamydia psittaci, CHLAP, LGV, Lymphogranuloma Venereum Serology, Ornithosis, Psittacosis Antibodies, SCLAM
Components
| Code | Name |
|---|---|
| RCLPNG | C. pneumoniae IgG |
| RCLPNM | C. pneumoniae IgM |
| RCLPSG | C. psittaci IgG |
| RCLPSM | C. psittaci IgM |
Interpretation
Method
Micro-Immunofluorescent Antibody (MIF)
Reference Range
See individual components
Ref. Range Notes
Interpretation:
Chlamydia pneumoniae IgM:
| <1:10 | IgM endpoint titers below 1:10 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels. |
| ≥1:10 | IgM endpoint titers of 1:10 or more are considered presumptive evidence of infection. |
Chlamydia pneumoniae IgG:
| <1:64 | IgG endpoint titers below 1:64 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels. |
| ≥1:64 and <1:512 | A single specimen endpoint titer of 1:64 to 1:512 should be considered evidence of infection at an undetermined time. A second specimen collected 10 to 21 days after the original collection should be tested in parallel with the first. If the second specimen exhibits a titer 1:512 or more or a 4-fold increase over that of the initial specimen, current (acute) infection is indicated. Unchanging titers from 1:64 to 1:512 suggest past infection. |
| ≥1:512 | IgG endpoint titers of 1:512 or more are considered presumptive evidence of current infection. |
C pneumoniae antibody is detectable in 25% to 45% of adults tested.
Chlamydia psittaci IgM:
| <1:10 | IgM endpoint titers below 1:10 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels. |
| ≥1:10 | IgM endpoint titers of 1:10 or more are considered presumptive evidence of infection. |
Chlamydia psittaci IgG:
| <1:64 | IgG endpoint titers below 1:64 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels. |
| ≥1:64 | IgG endpoint titers of 1:64 or more are considered presumptive evidence of current infection. |
Interferences and Limitations
Cautions:
Antichlamydial IgG can persist for years. All results from chlamydial serologies must correlate with clinical history and other data available to the physician.
Specimens collected too early during primary infection may not contain detectable antibodies. If chlamydial infection is suspected, a second specimen should be collected 10 to 21 days later and tested in parallel with the original specimen.
During a primary Chlamydia infection, the early antibody response may be cross-reactive with multiple Chlamydia species.
This assay does not report antibodies detected against Chlamydia trachomatis. Sera from suspected cases of lymphogranuloma venereum (LGV) should be tested by a Lymphogranuloma Venereum Differentiation Antibody Panel. LGV testing is not performed by Mayo Clinic Laboratories. Due to the limited sensitivity and specificity of Chlamydia serologic tests, patients with suspected C trachomatis infection should be tested by a molecular method when clinical manifestations are present.
Guidelines
Ordering & Collection
Specimen Type
Collection
3 mL blood in RED TOP tube or GOLD SST
Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 30 days; Frozen: 30 days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia.
Quantity
requested: 0.6 mL serum
minimum: 0.3 mL serum
Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: CHLAP.
- Interfaced: Yes.
- If acute and convalescent specimens are submitted, clearly indicate "acute" or "convalescent" on the sample label.
Stability: Refrigerated (preferred): 30 days; Frozen: 30 days; Ambient: Unacceptable.
Reject Due To: Gross hemolysis, gross lipemia.
Performance
LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
| Sendout |
Mayo Clinic Laboratories (Superior Drive)
800-533-1710 3050 Superior Drive NW |
|---|
Frequency
Performed: Monday - Friday; Report Available: 1-4 days.
Available STAT?
No