Clinical and Research Background
The focus of research in my lab, the X chromosome, provides a model for a naturally occurring “aneuploidy” caused by the evolution of a specific set of sex-determining chromosomes that differ in their copy number between males (XY) and females (XX). A fundamental issue in biology and medicine is to understand the effects of aneuploidy on gene expression and the mechanisms that alleviate imbalances of the genome. Such imbalances cause specific disorders including mental retardation and cancer. The X chromosome has evolved specific genetic and epigenetic mechanisms of dosage compensation, which we investigate using global approaches in terms of chromatin modifications during stem cell differentiation and embryo development. We are also interested in the impact of X-linked genes in producing sex-specific differences. My research is funded by grants from the NIGMS and NIMH.
Academic and Medical Appointments
Academic Appointments
Adjunct Professor of Medicine (Medical Genetics), University of Washington, Seattle, WA, 1996-Present
Professor of Pathology, University of Washington, Seattle, WA, 1992-Present
Associate Professor of Pathology, University of Washington, Seattle, WA, 1986-1992
Assistant Professor of Pathology, University of Washington, Seattle, WA, 1983-1986
Instructor of Pathology, University of Washington, Seattle, WA, 1980-1983
Medical Appointments
Director of the University of Washington Regional Cytogenetics Laboratory, Seattle, WA, 2011-Present
Co-director of the University of Washington Regional Cytogenetics Laboratory, Seattle, WA, 1980-2011
Education and Training
Postdoctoral Research Fellow, Harvard Medical School, Boston, MA, 1977-1980
Université de Liège, Belgium: Docteur en Sciences biomédicales expérimentales, 1970-1976
Université de Liège, Belgium: Licence en Sciences Zoologique, 1966-1970
Publications
Latest publications from PubMed