Publications

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SELECTED PUBLICATIONS​

1. The tragedy of mitotic catastrophe in podocytes.
   Shankland SJ, Najafian B, Wessely O. Kidney Int. 2024 Jun;105(6):1153-1156. doi:
   10.1016/j.kint.2024.01.015. PMID: 38777397.

2. Cardiomyocyte Globotriaosylceramide Accumulation in Adult Male Patients with Fabry Disease and IVS4 + 919G>A GLA Mutation is Progressive with Age and Correlates with Left
   Ventricular Hypertrophy and Reduced Left Ventricular Ejection Fraction.
   Chang FP, Hsu TR, Hung SC, Sung SH, Yu WC, Niu DM, Najafian B. medRxiv
   [Preprint]. 2023 Dec 11:2023.12.09.23298489. doi: 10.1101/2023.12.09.23298489.
   PMID: 38168318; PMCID: PMC10760261.

3. IgA-Dominant Infection-Related Glomerulonephritis.
   Paueksakon P, Najafian B, Alpers CE, Fogo AB. AJKD Atlas of Renal Pathology:
   Am J Kidney Dis. 2024
   Jan;83(1):e1-e2. doi: 10.1053/j.ajkd.2023.05.009. PMID: 38129071.

4. Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry,
   minimal change, and diabetic kidney diseases. 
   Smerkous D, Mauer M, Tøndel C, Svarstad E, Gubler MC, Nelson RG, Oliveira JP,
   Sargolzaeiaval F, Najafian B. Kidney Int. 2024
   Jan;105(1):165-176. doi: 10.1016/j.kint.2023.09.011. Epub 2023 Sep 27. PMID:
   37774924; PMCID: PMC10842003.

5. Synuclein α accumulation mediates podocyte injury in Fabrynephropathy.
   Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella
   J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig AK, Sachs W, von
   Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen
   MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-
   Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell
   C, Huber TB. J Clin Invest. 2023 Apr 4:e157782. doi: 10.1172/JCI157782. Epub
   ahead of print. PMID: 37014703.

6. Venglustat, an orally administered glucosylceramide synthase inhibitor: Assessment over 3 years in adult males with classic Fabry disease in an open-label phase 2 study and its
   extension study. 
   Deegan PB, Goker-Alpan O, Geberhiwot T, Hopkin RJ, Lukina E, Tylki-Szymanska
   A, Zaher A, Sensinger C, Gaemers SJM, Modur V, Thurberg BL, Sharma J, Najafian
   B, Mauer M, DasMahapatra P, Wilcox WR, Germain DP. Mol Genet Metab. 2023 Feb;138(2):106963. doi:
   10.1016/j.ymgme.2022.11.002. Epub 2022 Nov 9. PMID: 36481125; PMCID: PMC9918698.

7. Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes.
   Kobayashi H, Looker HC, Satake E, D'Addio F, Wilson JM, Saulnier PJ, Md Dom
   ZI, O'Neil K, Ihara K, Krolewski B, Badger HS, Petrazzuolo A, Corradi D, Galecki
   A, Wilson PC, Najafian B, Mauer M, Niewczas MA, Doria A, Humphreys BD, Duffin
   KL, Fiorina P, Nelson RG, Krolewski AS. Sci Transl Med. 2022 Aug 10;14(657):eabj2109.
   doi: 10.1126/scitranslmed.abj2109. Epub 2022 Aug 10. PMID: 35947673.

8. A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with
   Fabry disease. 
   Najafian B, Silvestroni A, Sokolovskiy A, Tøndel C, Svarstad E, Obrisca B,
   Ismail G, Holida MD, Mauer M. Kidney Int. 2022 Jul;102(1):173-182. doi:
   10.1016/j.kint.2022.03.023. Epub 2022 Apr 26. PMID: 35483528; PMCID: PMC9233139.

9. Divergent Impact of Enzyme Replacement Therapy on Human Cardiomyocytes and Enterocytes Affected by Fabry Disease: Correlation with
   Mannose-6-phosphate Receptor Expression.
   Frustaci A, Najafian B, Donato G, Verardo R, Chimenti C, Sansone L, Belli M,
   Vernucci E, Russo MA. J Clin Med. 2022 Feb 28;11(5):1344.
   doi: 10.3390/jcm11051344. PMID: 35268433; PMCID: PMC8911518.

10. A Diverse Spectrum of Immune Complex- and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma. 
    Andeen NK, Abdulameer S, Charu V, Zuckerman JE, Troxell M, Kambham N, Alpers
    CE, Najafian B, Nicosia RF, Smith KD, Kung VL, Avasare RS, Vallurupalli A,
    Jefferson JA, Hecox D, Swetnam L, Yamashita M, Lin M, Bissonnette ML, Akilesh S,
    Hou J. Kidney Int Rep. 2021 Dec
    27;7(3):568-579. doi: 10.1016/j.ekir.2021.12.020. PMID: 35257069; PMCID:
    PMC8897291.

11. Approach to Kidney Biopsy: Core Curriculum 2022.
    Najafian B, Lusco MA, Alpers CE, Fogo AB. Am J Kidney Dis. 2022 Jul;80(1):119-131. doi:
    10.1053/j.ajkd.2021.08.024. Epub 2022 Feb 4. PMID: 35125261.

12. Structural Lesions on Kidney Biopsy in Youth-Onset and Adult-Onset Type 2 Diabetes. 
    Looker HC, Pyle L, Vigers T, Severn C, Saulnier PJ, Najafian B, Mauer M,
    Nelson RG, Bjornstad P. Diabetes Care. 2022 Feb 1;45(2):436-443. doi:
    10.2337/dc21-1688. PMID: 35006272; PMCID: PMC8914414.

13. Serum Level of Polyubiquitinated PTEN and Loss of Kidney Function in American Indians With Type 2 Diabetes. 
    Looker HC, Lin C, Nair V, Kretzler M, Mauer M, Najafian B, Nelson RG. Am J Kidney Dis. 2022 Apr;79(4):497-506. doi:
    10.1053/j.ajkd.2021.08.009. Epub 2021 Sep 22. PMID: 34562525

14. Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease.
    Nelson RG, Knowler WC, Kretzler M, Lemley KV, Looker HC, Mauer M, Mitch WE, Najafian B, Bennett PH.Diabetes. 2021 Jul 20:dbi200043. doi: 10.2337/dbi20-0043. Online ahead of print.PMID: 34285119
15. Intraglomerular dysfunction predicts kidney failure in type 2 diabetes.
    Saulnier PJ, Looker HC, Mauer M, Najafian B, Gand E, Ragot S, Nelson RG, Bjornstad P.Diabetes. 2021 Jul 13:db210154. doi: 10.2337/db21-0154. Online ahead of print.PMID: 34257069
16. Renal Considerations in COVID-19: Part 1 Biology, Pathology and Pathophysiology.
    Kapp ME, Fogo AB, Roufouse C, Najafian B, Radhakrishnan J, Mohan S, Miller SE, D'Agati VD, Silberzweig JI, Barbar T, Gopalan T, Srivatana V, Mokrzycki MH, Benstein JA, Ng YH, Lentine KL, Aggarwal V, Perl J, Salenger P, Coyner J, Josephson MA, Heung M, Velez JC, Ikizler A, Vijayan A, William P, Thajudeen B, Slepian MJ.ASAIO J. 2021 Jun 29. doi: 10.1097/MAT.0000000000001530. Online ahead of print.PMID: 34191753
17. Comprehensive Search for Novel Circulating miRNAs and Axon Guidance Pathway Proteins Associated with Risk of End Stage Kidney Disease in Diabetes. Satake E, Saulnier PJ, Kobayashi H, Gupta M, Looker H, Wilson J, Md Dom Z, Ihara K, O'Neil K, Krolewski B, Pipino C, Pavkov M, Nair V, Bitzer M, Niewczas M, Kretzler M, Mauer M, Doria A, Najafian B, Kulkarni R, Duffin K, Pezzolesi M, Kahn CR, Nelson R, Krolewski A.J Am Soc Nephrol. 2021 Jun 17:ASN.2021010105. doi: 10.1681/ASN.2021010105. Online ahead of print.PMID: 34140396
18. Early Transplant Arteriopathy in Kidney Transplantation.
    Minnelli C, Riazy M, Ohashi R, Kowalewska J, Leca N, Najafian B, Smith KD, Nicosia RF, Alpers CE, Akilesh S.Transplant Proc. 2021 Jun;53(5):1554-1561. doi: 10.1016/j.transproceed.2021.02.019. Epub 2021 May 4.PMID: 33962774
19. SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function.
    Marchiano S, Hsiang TY, Khanna A, Higashi T, Whitmore LS, Bargehr J, Davaapil H, Chang J, Smith E, Ong LP, Colzani M, Reinecke H, Yang X, Pabon L, Sinha S, Najafian B, Sniadecki NJ, Bertero A, Gale M Jr, Murry CE.Stem Cell Reports. 2021 Mar 9;16(3):478-492. doi: 10.1016/j.stemcr.2021.02.008. Epub 2021 Feb 13.PMID: 33657418
20. Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria.
    Akilesh S, Nast CC, Yamashita M, Henriksen K, Charu V, Troxell ML, Kambham N, Bracamonte E, Houghton D, Ahmed NI, Chong CC, Thajudeen B, Rehman S, Khoury F, Zuckerman JE, Gitomer J, Raguram PC, Mujeeb S, Schwarze U, Shannon MB, De Castro I, Alpers CE, Najafian B, Nicosia RF, Andeen NK, Smith KD.Am J Kidney Dis. 2021 Jan;77(1):82-93.e1. doi: 10.1053/j.ajkd.2020.10.001. Epub 2020 Oct 10.PMID: 33045255
21. Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria.
    Akilesh S, Nast CC, Yamashita M, Henriksen K, Charu V, Troxell ML, Kambham N, Bracamonte E, Houghton D, Ahmed NI, Chong CC, Thajudeen B, Rehman S, Khoury F, Zuckerman JE, Gitomer J, Raguram PC, Mujeeb S, Schwarze U, Shannon MB, De Castro I, Alpers CE, Najafian B, Nicosia RF, Andeen NK, Smith KD.Am J Kidney Dis. 2021 Jan;77(1):82-93.e1. doi: 10.1053/j.ajkd.2020.10.001. Epub 2020 Oct 10.PMID: 33045255 
22. Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series.
    Bradley BT, Maioli H, Johnston R, Chaudhry I, Fink SL, Xu H, Najafian B, Deutsch G, Lacy JM, Williams T, Yarid N, Marshall DA.Lancet. 2020 Aug 1;396(10247):320-332. doi: 10.1016/S0140-6736(20)31305-2. Epub 2020 Jul 16.PMID: 32682491
23. Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss. Najafian B, Tøndel C, Svarstad E, Gubler MC, Oliveira JP, Mauer M. J Am Soc Nephrol. 2020 Mar 3. pii: ASN.2019050497. doi: 10.1681/ASN.2019050497.
24.  Fibrillary Glomerulonephritis: Clinicopathologic Features and Atypical Cases from a Multi-Institutional Cohort.
    Andeen NK, Troxell ML, Riazy M, Avasare RS, Lapasia J, Jefferson JA, Akilesh S, Najafian B, Nicosia RF, Alpers CE, Smith KD.Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1741-1750. doi: 10.2215/CJN.03870319. Epub 2019 Nov 4.PMID: 31685544
25. Changes in Albuminuria But Not GFR are Associated with Early Changes in Kidney Structure in Type 2 Diabetes. J Am Soc Nephrol. 2019 Jun;30(6):1049-1059. doi: 10.1681/ASN.2018111166.
26. Low-dose agalsidase beta treatment in male pediatric patients with Fabry disease: A 5-year randomized controlled trial. Mol Genet Metab. 2019 May;127(1):86-94. doi: 10.1016/j.ymgme.2019.03.010. Epub 2019 Apr 3.
27. White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes. Nephrol Dial Transplant. 2017 Dec 1;32(12):2145. doi: 10.1093/ndt/gfx303.
28. Volumetric, Nanoscale Optical Imaging of Mouse and Human Kidney via Expansion Microscopy. Chozinski TJ, Mao C, Halpern AR, Pippin JW, Shankland SJ, Alpers CE, Najafian B, Vaughan JC. Sci Rep. 2018 Jul 10;8(1):10396. doi: 10.1038/s41598-018-28694-2. PMID: 29991751
29. Wheelock KM, Saulnier PJ, Tanamas SK, Vijayakumar P, Weil EJ, Looker HC, Hanson RL, Lemley KV, Yee B, Knowler WC, Hadjadj S, Najafian B, Mauer M, Nelson RG. White blood cell fractions correlate with lesions of diabetic kidney disease and predict loss of kidney function in Type 2 diabetes. Nephrol Dial Transplant. 2017 Jul 18. doi: 10.1093/ndt/gfx231. [Epub ahead of print]
30. Mauer M, Sokolovskiy A, Barth J, Castelli J, Williams H, Elfrida B, Najafian B. Reduction of podocyte globotriaosylceramide content in adult male Fabry patients with amenable GLA mutation following 6-months of migalastat treatment. J Med Gen 2017; 54(11):781-786
31. Courtade JA, Klimek-Abercrombie AM, Chen Y, Patel N, Lu PYT, Speake C, Orban PC, Najafian B, Meneilly G, Greenbaum CJ, Warnock GL, Panagiotopoulos C, Verchere CB. Measurement of pro-islet amyloid polypeptide (1-48) in diabetes and islet transplants. J Clin Endocrin Metabol 2017;102(7):2595-2603
32. Schiffmann R, Hughes DA, Linthorst GE, Ortiz A, Svarstad E, Warnock DG, West ML, Wanner C, Cinference Participants. Screening, diagnosis, and management of patients with Fabry disease: conclusions from a “Kidney Disease: Improving Global Outcomnes” (KDIGO) Controversies Conference. Kidney Int 2017;91:284-293
33. Tower CM, Reyes M, Nelson K, Leca N, Kieran N, Muczynski K, Jefferson A, Blosser C, Kukla A, Maurer D, Chandler W, Najafian B. Plasma C4d+ endothelial microvesicles increase in acute antibody-mediated rejection. Transplantation 2017;101(9):2235-2243.
34. Fall B, Scott CR, Mauer M, Shankland S, Pippin J, Jefferson JA, Wallace E, Warnock D, Najafian B. Urinary podocyte loss is increased in patients with Fabry disease and correlates with clinical severity of Fabry nephropathy. PLoS One 2016; 11:e0168346
35. Najafian B, Tondel C, Svarstad E, Sokolovskyi A, Smith K, Mauer M. One year of enzyme replacement therapy reduces globotriaosylceramide inclusions in podocytes in male adult patients with Fabry disease. PLoS One 11(4): e0152812, 2016.
36. Andeen NK, Nguyen TQ, Steegh F, Hudkins KL, Najafian B, Alpers CE. Overlapping phenotypes of podocytes and parietal epithelial cells in diabetic nephropathy. Kidney Int 88(5):1099-107, 2015.
37. Wijburg FA, Bénichou B, Bichet DG, Clarke LA, Dostalova G, Fainboim A, Fellgiebel A, Forcelini C, An Haack K, Hopkin RJ, Mauer M, Najafian B, Scott CR, Shankar SP, Thurberg BL, Tøndel C, Tylki-Szymańska A, Ramaswami U. Characterization of early disease status in treatment-naive male paediatric patients with fabry disease enrolled in a randomized clinical trial. PLoS One 2015 May 8;10(5):e0124987
38. Mauer M, Glynn E, Svarstad E, Tondel C, Gubler MC, West M, Sokolovsky A, Najafian B. Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease. PLOS ONE 9: e112188, 2014
39.  Mauer M, Caramori ML, Fioretto P, Najafian B. Glomerular structural-functional relationship models are robust in diabetic nephropathy in type 1 diabetes. Nephrol Dial Transplant pii: gfu279, 2014
40. Hart A, Jackson S, Kasiske BL, Mauer MS, Najafian B, Matas AJ, Spong R, Ibrahim HN. Uric acid and allograft loss from interstitial fibrosis/tubular atrophy: post hoc analysis from the angiotensin II blockade in chronic allograft nephropathy trial. Transplantation 97:1066-71, 2014
41. Issa N, Ortiz F, Reule SA, Kukla A, Kasiske BL, Mauer M, Jackson S, Matas AJ, Ibrahim HN, Najafian B. The renin-aldosterone axis in kidney transplant recipients and its association with allograft function and structure. Kidney Int. 2015;87(1):243.
42. Najafian B and Mauer M. Predilection of the segmental glomerulosclerosis lesions for the glomerulotubular junction area in type 1 diabetic patients: a novel mapping method. PLOS ONE, 8(7):e69253, 2013.
43.  Ibrahim HN, Jackson S, Connaire J, Matas A, Ney A, Najafian B, West A, Lentsch J, Ericksen J, Bodner J, Kasiske B, Mauer M. Angiotensin II blockade in kidney transplant recipients. J Am Soc Nephrol 24: 320-327, 2013
44. Verghese P, Dunn T, Najafian B, Kim Y, Matas A. The impact of C4d and microvascular inflammation before we knew them. Clin Transplant 2013, 27: 388-396.
45. Zuo Y, Yang HC, Potthoff SA, Najafian B, Kon V, Ma LJ, Fogo AB. Protective effects of PPAR{gamma} agonist in acute nephrotic syndrome. Nephrol Dial Transpl 27:174-181, 2012.
46. Park HW, Kim Y, Kim KH, Najafian B, Mauer M. Angiotensin II receptor blocker pretreatment of rats undergoing sudden renal ablation. Nephrol Dial Transplant 27:107-114, 2012.
47. Najafian B, Mauer M. Quantitating endothelial fenestration: An unbiased stereological approach. Am J Nephrol 33 (Suppl 1): 34-39,2011.
48. Najafian B, Masood A, Malloy P, Alfonso C, Hansen B, Mauer M, Caramori ML. Glomerulopathy in spontaneously obese Rhesus monkeys with type 2 diabetes: A stereological study. Diab Metabol Res Rev 27:341-347, 2011
49. Najafian B, Svarstad E, Bostad L, Gubler M, Tøndel C, Whitley C, Mauer M. Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease. Kidney Int, 79:663-670, 2011
50. Fioretto P, Najafian B, Sutherland DER, Mauer M. Tacrolimus and cyclosporine nephrotoxicity in native kidneys of diabetic pancreas transplant recipients. Clin J Am Soc Nephrol 6:101-106, 2011
51. Najafian B, Franklin D, Fogo A.  Acute renal failure and myalgia in a transplant patient.  J Am Soc Nephrol, 18: 2870-4, 2007
52. Toyoda M, Najafian B, Kim Y, Caramori ML, Mauer M.  Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy.  Diabetes 56:1-7, 2007
53. Najafian B, Crosson JT, Kim Y, Mauer M.  Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes.   J Am Soc Nephrol 17 Suppl 2:S53-60, 2006.
54. Fioretto P, Sutherland DER, Najafian B, Mauer M.  Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients.  Kidney Int 69: 907-912, 2006.
55. Najafian B, Kim Y, Crosson JT, Mauer M: Atubular glomeruli and glomerulotubular junction abnormalities in diabetic nephropathy. J Am Soc Nephrol 14: 908-917, 2003
56. Najafian B, Basgen MJ, Mauer M: Estimating mean glomerular volume using two arbitrary parallel sections. J Am Soc Nephrol 13:2697-2705, 2002