Raj Kapur, MD, PhD, Professor, Pathology, Seattle Children’s Hospital

Location: UWMC, NE110 conference room

Summary: Why Attend?
Many conditions presented to the pediatric pathology are rare and have a genetic basis. The chance encounter of two such lesions, placental mesenchymal dysplasia and hepatic mesenchymal hamartoma, in a single patient suggested a common pathogenetic basis, and opportunities to learn more about potential molecular “underpinnings” for these seemingly disparate entities. Learn how a series of investigations, conducted primarily with resources in the clinical laboratory, have helped explain this association and implicated expression of a cluster of evolutionarily new miRNAs in hepatic hamartoma formation.