Recent Publications Since 2016

  1. Sheng L, Stewart T, Yang D, Thorland E, Soltys D, Aro P, Khrisat T, Xie Z, Li N, Liu Z, Tian C, Bercow M, Matsumoto J, Zabetian CP, Peskind E, Quinn JF, Shi M, Zhang J. (2020) Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. Acta Neuropathol Commun, 8(1):102. doi: 10.1186/s40478-020-00983-w. PMID: 32641150, PMCID: PMC7346449
  2. Yu Z, Shi M, Stewart T, Fernagut P-O, Huang Y, Tian C, Dehay B, Atik A, Yang D, De Giorgi F, Ichas F, Canron M-H, Ceravolo R, Frosini D, Kim H-J, Feng T, Meissner WG, Zhang J. (2020) Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction. Brain, 143(6):1780-1797. doi: 10.1093/brain/awaa110. PMID: 32428221, PMCID: PMC7296853
  3. Dong Y, Stewart T, Bai L, Li X, Xu T, Iliff J, Shi M, Zheng D, Yuan L, Wei T, Yang X, Zhang J. (2020) Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets. Theranostics, 10(1): 179-200. doi: 10.7150/thno.36722. eCollection 2020. PMID: 31903114, PMCID: PMC6929631
  4. Tian C, Liu G, Gao L, Soltys D, Pan C, Stewart T, Shi M, Xie Z, Liu N, Feng T, Zhang J. (2019) Erythrocytic α-Synuclein as a potential biomarker for Parkinson's disease. Transl Neurodegener, 8: 15. doi: 10.1186/s40035-019-0155-y. eCollection 2019. PMID: 31123587, PMCID: PMC6521422
  5. Stewart T, Shi M, Mehrotra A, Aro P, Soltys D, Kerr KF, Zabetian CP, Peskind ER, Taylor P, Shaw LM, Trojanowski JQ, Zhang J; and from the Alzheimer’s Disease Neuroimaging Initiative. (2019) Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers. J Alzheimers Dis, 69(1): 263-276. doi: 10.3233/JAD-190069. PMID: 30958379, PMCID: PMC6513710
  6. Shi M, Sheng L, Stewart T, Zabetian CP, Zhang J. (2019) New windows into the brain: Central nervous system-derived extracellular vesicles in blood. Prog Neurobiol, 175: 96-106. Review. doi: 10.1016/j.pneurobio.2019.01.005. PMID: 30685501, PMCID: PMC6546433
  7. Cilento EM, Jin L, Stewart T, Shi M, Sheng L, Zhang J. (2019) Mass Spectrometry: A Platform for Biomarker Discovery and Validation for Alzheimer's and Parkinson's Diseases. J Neurochem, 151(4): 397-416. Review. doi: 10.1111/jnc.14635. PMID: 30474862, PMCID: PMC6535381
  8. Wang H, Atik A, Stewart T, Ginghina C, Aro P, Kerr KF, Seibyl J, Jennings D; PARS Investigators, Jensen PH, Marek K, Shi M, Zhang J. (2018) Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study. Neurobiol Dis, 116: 53-59. doi: 10.1016/j.nbd.2018.04.015. PMID: 29705185, PMCID: PMC6294306
  9. Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, Shaw LM, Trojanowski JQ, Zhang J. (2018) Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimers Dement, 14(8): 1052-1062. doi: 10.1016/j.jalz.2018.02.015. PMID: 29604263, PMCID: PMC6097943
  10. Wang H, Stewart T, Toledo JB, Ginghina C, Tang L, Atik A, Aro P, Shaw LM, Trojanowski JQ, Galasko DR, Edland S, Jensen PH, Shi M, Zhang J; Alzheimer’s Disease Neuroimaging Initiative. (2018) A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. J Alzheimers Dis, 61(4): 1541-1553. doi: 10.3233/JAD-171013. PMID: 29376878, PMCID: PMC5828159
  11. Yu Z, Stewart T, Aasly J, Shi M, Zhang J. (2018) Combining clinical and biofluid markers for early Parkinson's disease detection. Ann Clin Transl Neurol, 5(1): 109-114. doi: 10.1002/acn3.509. PMID: 29376098, PMCID: PMC5771326
  12. Matsumoto J, Stewart T, Banks WA, Zhang J. (2017) The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier. Curr Pharm Des, 23(40): 6206-6214. doi: 10.2174/1381612823666170913164738. Review. PMID: 28914201
  13. Matsumoto J, Stewart T, Sheng L, Li N, Bullock K, Song N, Shi M, Banks WA, Zhang J. (2017) Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease? Acta Neuropathol Commun, 5(1): 71. doi: 10.1186/s40478-017-0470-4. PMID: 28903781, PMCID: PMC5598000
  14. Yang L, Stewart T, Shi M, Pottiez G, Dator R, Wu R, Aro P, Schuster RJ, Ginghina C, Pan C, Gao Y, Qian W, Zabetian CP, Hu SC, Quinn JF, Zhang J. (2017) An alpha-synuclein MRM assay with diagnostic potential for Parkinson's disease and monitoring disease progression. Proteomics Clin Appl, 11(7-8): 1700045. doi: 10.1002/prca.201700045. PMID: 28319654, PMCID: PMC5540649
  15. Pottiez G, Yang L, Stewart T, Song N, Aro P, Galasko D, Quinn J, Peskind E, Shi M, Zhang J. (2017) A mass spectrometry-based method to quantify in parallel Tau and amyloid β 1-42 in CSF for the diagnostic of Alzheimer's Disease. J Proteome Res, 16(3): 1228-1238. doi: 10.1021/acs.jproteome.6b00829. PMID: 28112948, PMCID: PMC5679294
  16. Banks WA, Kovac A, Majerova P, Bullock KM, Shi M, Zhang J. (2017) Tau Proteins Cross the Blood-Brain Barrier. J Alzheimers Dis, 55(1): 411-419. doi: 10.3233/JAD-160542. PMID: 27662303
  17. Shi M, Kovac A, Korff A, Cook TJ, Ginghina C, Bullock KM, Yang L, Stewart T, Zheng D, Aro P, Atik A, Kerr KF, Zabetian CP, Peskind ER, Hu SC, Quinn JF, Galasko DR, Montine TJ, Banks WA, Zhang J. (2016) CNS tau efflux via exosomes is likely increased in Parkinson disease but not in Alzheimer disease. Alzheimers Dement, 12(11): 1125-1131. doi: 10.1016/j.jalz.2016.04.003. PMID: 27234211, PMCID: PMC5107127
  18. Wang S, Chu CH, Guo M, Jiang L, Nie H, Zhang W, Wilson B, Yang L, Stewart T, Hong JS, Zhang J. (2016) Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons. J Neuroinflammation, 13(1): 158. doi: 10.1186/s12974-016-0606-7. PMID: 27329107, PMCID: PMC4915166
  19. Atik A, Stewart T, Zhang J. (2016) Alpha-Synuclein as a Biomarker for Parkinson's Disease. Brain Pathol, 26(3): 410-418. doi: 10.1111/bpa.12370. Review. PMID: 26940058, PMCID: PMC6245641
  20. Hossein-Nezhad A, Fatemi RP, Ahmad R, Peskind ER, Zabetian CP, Hu SC, Shi M, Wahlestedt C, Zhang J, Faghihi MA. (2016) Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Diseases. J Parkinsons Dis, 6 (1): 109-117. doi: 10.3233/JPD-150737. PMID: 26889637, PMCID: PMC4927907

Principle Investigators

Min Shi, PhD
Tessandra Stewart, PhD

Contact

Patrick Aro
Research Scientist & Lab Manager
paro@uw.edu
Lab: (206) 543-3310

 

correspondence:

UW, Harborview Medical Center
Stewart and Shi Lab
325 Ninth Avenue, Box 359635
Seattle, WA 98104

 

shipping:

UW, School of Medicine 
1959 NE Pacific Street
Health Science Building, D-518
Pathology Department, Box 357470
Seattle, WA  98195