Selected Publications Prior to 2016

  • Biomarkers for PD/AD

    1. Stewart T, Liu C, Ginghina C, Cain KC, Auinger P, Cholerton B, Shi M, Zhang J; Parkinson Study Group DATATOP Investigators. (2014) Cerebrospinal fluid α-synuclein predicts cognitive decline in Parkinson disease progression in the DATATOP cohort. Am J Pathol, 184(4): 966-975. doi: 10.1016/j.ajpath.2013.12.007. PMID: 24625392, PMCID: PMC3969999

    2. Zhang J, Mattison HA, Liu C, Ginghina C, Auinger P, McDermott MP, Stewart T, Kang UJ; The Parkinson Study Group DATATOP Investigators, Cain KC, Shi M. (2013) Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease. Acta Neuropathol, 126(5): 671-682. doi: 10.1007/s00401-013-1121-x. PMID: 23644819, PMCID: PMC3796193

    3. Korff A, Liu C, Ginghina C, Shi M, Zhang J. (2013) α-Synuclein in cerebrospinal fluid of Alzheimer’s disease and mild cognitive impairment. J Alzheimers Dis, 36(4): 679-688. doi: 10.3233/JAD-130458. PMID: 23603399, PMCID: PMC3740054

    4. Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM-Y, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, Hasegawa M, Lin X, Pan C, Galasko D, Goldstein DS, Jensen PH, Yang H, Cain KC, Zhang J. (2012) Phosphorylated α-synuclein in Parkinson’s disease. Sci Transl Med, 4: 121ra20. doi: 10.1126/scitranslmed.3002566. PMID: 22344688, PMCID: PMC3302662

    5. Devic I, Hwang H, Edgar JS, Izutsu K, Presland R, Pan C, Goodlett DR, Wang Y, Armaly J, Tumas V, Zabetian CP, Leverenz JB, Shi M, Zhang J. (2011) Salivary α-synuclein and DJ-1: Potential biomarkers for Parkinson’s disease. Brain, 134(Pt 7): e178. doi: 10.1093/brain/awr015. PMID: 21349902, PMCID: PMC3122368

    6. Shi M, Bradner J, Hancock AM, Chunag KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Kim HM, Leverenz JB, Montine TJ, Ginghina C, Kang UJ, Cain KC, Wang Y, Aasly J, Goldstein D, Zhang J. (2011) Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol, 69(3): 570-580. doi: 10.1002/ana.22311. PMID: 21400565, PMCID: PMC3117674
      *** Featured in “Research Highlights” (Nature Reviews Neurology 2011, 7:1), “New developments in CSF biomarkers for early detection and monitoring of Parkinson disease”:***

    1. Shi M, Zhang J. (2011) Cerebrospinal fluid α-synuclein, tau and amyloid β in Parkinson’s disease. Lancet Neurol, 10(8): 681. doi: 10.1016/S1474-4422(11)70130-2. Comment. PMID: 21777821

    2. Hong Z, Shi M, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Leverenz JB, Baird G, Montine TJ, Hancock AM, Hwang H, Pan C, Bradner J, Kang UJ, Jensen PH, Zhang J. (2010) DJ-1 and a-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease. Brain, 133(Pt 3): 713-726. doi: 10.1093/brain/awq008. PMID: 20157014, PMCID: PMC2842513
      *** Featured in “News & Views” (Nature Reviews Neurology 2010, 6:359), “Progress towards a molecular biomarker for Parkinson disease”: ***

  • Brain-peripheral blood communication and extracellular vesicles

    1. Shi M, Liu C, Cook TJ, Bullock KM, Zhao Y, Ginghina C, Li Y, Aro P, Dator R, He C, Hipp MJ, Zabetian CP, Peskind ER, Hu SC, Quinn JF, Galasko DR, Banks WA, Zhang J. (2014) Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol, 128(5): 639-650. doi: 10.1007/s00401-014-1314-y. PMID: 24997849, PMCID: PMC4201967
    2. Sui YT, Bullock KM, Erickson MA, Zhang J, Banks WA. (2014) Alpha synuclein is transported into and out of the brain by the blood-brain barrier. Peptides, 62: 197-202. doi: 10.1016/j.peptides.2014.09.018. PMID: 25278492, PMCID: PMC4378645
  • Extracellular α-synuclein and glia in PD

    1. Wang S, Chu CH, Stewart T, Ginghina C, Wang Y, Nie H, Guo M, Wilson B, Hong JS, Zhang J. (2015) α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation. Proc Natl Acad Sci U S A, 112(15): E1926-35. doi: 10.1073/pnas.1417883112. PMID: 25825709, PMCID: PMC4403145.
    2. Hoekstra JG, Cook TJ, Stewart T, Mattison H, Dreisbach MT, Hoffer ZS, Zhang J. (2015) Astrocytic dynamin-like protein 1 regulates neuronal protection against excitotoxicity in Parkinson disease. Am J Pathol, 185(2): 536-49. doi: 10.1016/j.ajpath.2014.10.022. PMID: 25482923, PMCID: PMC4305181
    3. Liu J, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J. (2009) Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. J Neurosci, 29(5): 1480-1485. doi: 10.1523/JNEUROSCI.6202-08.2009. PMID: 19193894, PMCID: PMC3241981
    4. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J. (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J, 19(6): 533-42. doi: 10.1096/fj.04-2751com. PMID: 15791003
  • Proteomics and its applications in PD/AD

    1. Shi M, Movius J, Dator R, Aro P, Zhao Y, Pan C, Lin X, Bammler TK, Stewart T, Zabetian CP, Peskind ER, Hu SC, Quinn JF, Galasko DR, Zhang J. (2015) Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation. Mol Cell Proteomics, 14(3): 544-555. doi: 10.1074/mcp.M114.040576. PMID: 25556233, PMCID: PMC4349976

    2. Pan C, Zhou Y, Dator R, Ginghina C, Zhao Y, Movius J, Peskind E, Zabetian CP, Quinn J, Galasko D, Stewart T, Shi M, Zhang J. (2014) Targeted discovery and validation of plasma biomarkers of Parkinson's disease. J Proteome Res, 13(11): 4535-4545. doi: 10.1021/pr500421v. PMID: 24853996, PMCID: PMC4224986

    3. Lin X, Cook TJ, Zabetian CP, Leverenz JB, Peskind ER, Hu SC, Cain KC, Pan C, Edgar JS, Goodlett DR, Racette BA, Checkoway H, Montine TJ, Shi M, Zhang J. (2012) DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease. Sci Rep, 2: 954. doi: 10.1038/srep00954. PMID: 23233873, PMCID: PMC3518819

    4. Shi M, Bradner J, Bammler TK, Eaton DL, Zhang J, Ye Z, Wilson AM, Montine TJ, Pan C, Zhang J. (2009) Identification of glutathione S-transferase Pi as a protein involved in Parkinson disease progression. Am J Pathol, 175(1): 54-65. doi: 10.2353/ajpath.2009.081019. PMID: 19498008, PMCID: PMC2708794

    5. Shi M, Jin J, Wang Y, Beyer RP, Kitsou E, Albin RL, Gearing M, Pan C, Zhang J. (2008) Mortalin: A protein associated with progression of Parkinson disease? J Neuropathol Exp Neurol, 67(2): 117-124. doi: 10.1097/nen.0b013e318163354a. PMID: 18219256

    6. Pan S, Shi M, Jin J, Albin RL, Lieberman A, Gearing M, Lin B, Pan C, Yan X, Kashima DT, Zhang J. (2007) Proteomics identification of proteins in human cortex using multi-dimensional separations and MALDI tandem mass spectrometer. Mol Cell Proteomics, 6(10): 1818-1823. PMID: 17644759 [full text]