Neuro-oncology Brain Repository
The UW Neuro-oncology Brain Repository is the first of its kind, leveraging world-class expertise in neuropathology and neuroscience research to study the biology and evolution of glioblastoma and other types of brain cancer.
Our mission: to honor and learn
Our mission is to honor the legacy of patients with this terrible disease and to learn how the disease develops, how it impacts the brain and the individual, how treatments alter this course and how the tumor responds to evade treatment. Through analysis using a variety of traditional and cutting-edge technologies, it is our hope that we can learn how brain cancers and their treatments affect both the tumor cells and healthy brain tissue, identify potential therapeutic targets, and ultimately use this information to advance therapeutic options for future patients.
Ultimately we envision the autopsy program to work hand in hand with studies on neurosurgical resection specimens from the Neurosurgical Tissue Repository (NTR). Specifically, the goals for the Neurooncology Brain Repository (in conjunction with and requisite for) studies of NTR specimens are to:
- Understand molecular evolution of gliomas, particularly in association with surgical, radiation, and chemotherapeutic interventions, to understand mechanisms/pathways of tumor progression and to develop strategies to impede this process.
- Develop a living biobank from initial resection, re-resection, and brain autopsy materials to probe for mechanisms and test current and novel therapeutics with respect to tumor progression and molecular pathway changes as gliomas evolve.
- Using clinical and post-mortem (ex vivo) imaging, correlate neuropathological changes with radiographic and clinical features to better understand and develop biomarkers sensitive to tumor progression and other processes such as radiation necrosis.
- Understand the mechanisms of neurotoxicity to the brain caused by adjuvant therapies in order to design better targeted therapeutics that have reduced side effect profiles.
Principal Investigators
Questions about Brain Donation?
Email us at uwnp@uw.edu, or call 206-897-5453.
BRaIN Lab Contacts
Lab Manager
awilson@uw.edu, Phone: 206-897-5246
Brain Bank & Research Manager
aschantz@uw.edu, Phone: 206-616-0517
Operations Director for Neuropathology Activities
ragaglia@uw.edu, Phone: 206-221-9247
Brain Donor Network (BDN) Project Manager
lmkeene@uw.edu, Phone: 206-897-5248
Give to the BRaIN Lab & Neuropathology
Together UW Gift Campaigns
A Husky for Life - Jim Lambright
In Memory of Matthew Dahl
In Memory of our Darene
Seeking Treatments for the Injured Brain
Traumatic Brain Injury Research
The One, The Only, The Best - Patrick Koeplin
UW Medicine Gift Funds
Mailing & Shipping
General mail: HMC Keene Lab, 325 Ninth Avenue, MS 359645, Seattle, WA 98104 [map]
Overnight shipping: Emily Ragaglia, HMC-NJB, 2nd floor, room 273, 908 Jefferson Street, Seattle, WA 98104, Phone: 206-221-9247
For VA Puget Sound locations: contact Angela Wilson, awilson@uw.edu
Connect with the BRaIN Lab
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